南方科技大学知识苑(SUSTech KC): Transposable Elements in Pluripotent Stem Cells and Human Disease

题名	Transposable Elements in Pluripotent Stem Cells and Human Disease
作者	Ma, Gang; Babarinde, Isaac A.; Zhou, Xuemeng; Hutchins, Andrew P.
通讯作者	Hutchins, Andrew P.
发表日期	2022-06-02
DOI	10.3389/fgene.2022.902541
发表期刊	FRONTIERS IN GENETICS 影响因子和分区
EISSN	1664-8021
卷号	13
摘要	Transposable elements (TEs) are mobile genetic elements that can randomly integrate into other genomic sites. They have successfully replicated and now occupy around 40% of the total DNA sequence in humans. TEs in the genome have a complex relationship with the host cell, being both potentially deleterious and advantageous at the same time. Only a tiny minority of TEs are still capable of transposition, yet their fossilized sequence fragments are thought to be involved in various molecular processes, such as gene transcriptional activity, RNA stability and subcellular localization, and chromosomal architecture. TEs have also been implicated in biological processes, although it is often hard to reveal cause from correlation due to formidable technical issues in analyzing TEs. In this review, we compare and contrast two views of TE activity: one in the pluripotent state, where TEs are broadly beneficial, or at least mechanistically useful, and a second state in human disease, where TEs are uniformly considered harmful.
关键词	transposable element (TE) endogenous retrovirus (ERV) long terminal repeat (LTR) pluripotent stem cell (PSC) non-coding RNA (ncRNAs)
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[31970589] ; Shenzhen Innovation Committee of Science and Technology["JCYJ20200109141018712","ZDSYS20200811144002008"]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000812059300001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/343035
专题	生命科学学院_生物系生命科学学院
作者单位	Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen Key Lab Gene Regulat & Syst Biol, Shenzhen, Peoples R China
第一作者单位	生物系; 生命科学学院
通讯作者单位	生物系; 生命科学学院
第一作者的第一单位	生物系; 生命科学学院
推荐引用方式 GB/T 7714	Ma, Gang,Babarinde, Isaac A.,Zhou, Xuemeng,et al. Transposable Elements in Pluripotent Stem Cells and Human Disease[J]. FRONTIERS IN GENETICS,2022,13.
APA	Ma, Gang,Babarinde, Isaac A.,Zhou, Xuemeng,&Hutchins, Andrew P..(2022).Transposable Elements in Pluripotent Stem Cells and Human Disease.FRONTIERS IN GENETICS,13.
MLA	Ma, Gang,et al."Transposable Elements in Pluripotent Stem Cells and Human Disease".FRONTIERS IN GENETICS 13(2022).