南方科技大学知识苑(SUSTech KC): CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells

题名	CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells
作者	Schuster, Cornelia 1; Kiaf, Badr 1; Hatzihristidis, Teri 2; Ruckdeschel, Anna 1; Nieves-Bonilla, Janice 1; Ishikawa, Yuki 1; Zhao, Bin 2,4; Zheng, Peilin 3,5; Love, Paul E.2; Kissler, Stephan 1
通讯作者	Kissler, Stephan
发表日期	2022-06-02
DOI	10.3389/fimmu.2022.906499
发表期刊	Frontiers in Immunology 影响因子和分区
ISSN	1664-3224
卷号	13
摘要	CD5 is constitutively expressed on all T cells and is a negative regulator of lymphocyte function. However, the full extent of CD5 function in immunity remains unclear. CD5 deficiency impacts thymic selection and extra-thymic regulatory T cell generation, yet CD5 knockout was reported to cause no immune pathology. Here we show that CD5 is a key modulator of gut immunity. We generated mice with inducible CD5 knockdown (KD) in the autoimmune-prone nonobese diabetic (NOD) background. CD5 deficiency caused T cell-dependent wasting disease driven by chronic gut immune dysregulation. CD5 inhibition also exacerbated acute experimental colitis. Mechanistically, loss of CD5 increased phospho-Stat3 levels, leading to elevated IL-17A secretion. Our data reveal a new facet of CD5 function in shaping the T cell cytokine profile.
关键词	T cell costimulation autoimmunity cytokines mouse model
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:000812094200001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：3
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/343055
专题	南方科技大学第一附属医院
作者单位	1.Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA 2.NIH, Sect Hematopoiesis & Lymphocyte Biol, Eunice Kennedy Shriver Natl Inst Child Hlth & Huma, Bethesda, MD USA 3.Rudolf Virchow Ctr Expt Biomed, Wurzburg, Germany 4.Cent South Univ, Xiangya Hosp 2, Dept Metab & Endocrinol, Changsha, Hunan, Peoples R China 5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1,Clin Med C, Dept Endocrinol, Shenzhen, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Schuster, Cornelia,Kiaf, Badr,Hatzihristidis, Teri,et al. CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells[J]. Frontiers in Immunology,2022,13.
APA	Schuster, Cornelia.,Kiaf, Badr.,Hatzihristidis, Teri.,Ruckdeschel, Anna.,Nieves-Bonilla, Janice.,...&Kissler, Stephan.(2022).CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells.Frontiers in Immunology,13.
MLA	Schuster, Cornelia,et al."CD5 Controls Gut Immunity by Shaping the Cytokine Profile of Intestinal T Cells".Frontiers in Immunology 13(2022).