南方科技大学知识苑(SUSTech KC): Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation

题名	Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation
作者	Luo, Biwei 1,2,3; Liu, Linsen 1,2,3; Bi, Jian'gang 1,2,3; Bao, Shiyun 1,2,3; Zhang, Yusen 1,2,3
通讯作者	Zhang, Yusen
发表日期	2022-06-01
DOI	10.1177/03936155221101075
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 影响因子和分区
ISSN	0393-6155
EISSN	1724-6008
摘要	Objective This study aimed to investigate the role of the alpha fetoprotein (AFP) ratio before and after radiofrequency ablation (RFA) in the prognosis of patients with liver cancer. Methods A total of 368 patients who underwent RFA for liver cancer in Shenzhen People's Hospital from 2010 to 2020 were randomly divided into the training group and the validation group. Levels of AFP before and after RFA were recorded and their ratios were calculated. Results Using the X-tile software, it was found that the optimal cut-off value of the AFP ratio in the training group was 37.9. Both in the training group and the validation group, the relapse-free survival and overall survival of patients with an AFP ratio <37.9 (high-risk group) were significantly shorter than those with an AFP ratio >37.9 (low-risk group) (training group, relapse-free survival, P = 0.0003; overall survival, P = 0.0186; validation group, relapse-free survival, P = 0.0490, overall survival, P = 0.0031). An AFP ratio Conclusion The AFP ratio can predict the prognosis of patients with liver cancer after RFA. An AFP ratio <37.9 is an independent risk factor for tumor recurrence and survival after RFA.
关键词	Liver cancer radiofrequency ablation alpha fetoprotein survival recurrence
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Natural Science Foundation of China["A2021230","SZXK015",52077216]
WOS研究方向	Biotechnology & Applied Microbiology ; Oncology
WOS类目	Biotechnology & Applied Microbiology ; Oncology
WOS记录号	WOS:000811526500001
出版者	SAGE PUBLICATIONS LTD
ESI学科分类	CLINICAL MEDICINE
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/343059
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Clin Med Coll 2, Dept Hepatobiliary & Pancreas Surg, ShenZhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China 3.ShenZhen Peoples Hosp, Dept Gen Surg, Shenzhen, Guangdong, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Luo, Biwei,Liu, Linsen,Bi, Jian'gang,et al. Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2022.
APA	Luo, Biwei,Liu, Linsen,Bi, Jian'gang,Bao, Shiyun,&Zhang, Yusen.(2022).Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS.
MLA	Luo, Biwei,et al."Role of the pre- to postoperative alpha-fetoprotein ratio in the prognostic evaluation of liver cancer after radiofrequency ablation".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS (2022).