Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape

Cai, Yuting1,2,3; Huang, Qun4,5; Wang, Penghui4; Ye, Kaichuang4,5; Zhao, Zhen4,5; Chen, Haomin6; Liu, Zhenjing2,3; Liu, Hongwei2,3; Wong, Hoilun2,3; Tamtaji, Mohsen2,3; Zhang, Kenan2,3; Xu, Feng7; Jin, Guorui7; Zeng, Lun8; Xie, Jianbo8; Du, Yucong8; Hu, Zhigang9; Sun, Dazhi1; Qin, Jinbao4,5; Lu, Xinwu4,5; Luo, Zhengtang2,3

2022-06-01

10.1002/adhm.202200755

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Diabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia and microvascular complications. This study develops a graphene-based nerve guidance conduit by incorporating natural double network hydrogel and a neurotrophic concentration gradient with non-invasive treatment for diabetics. GelMA/silk fibroin double network hydrogel plays quadruple roles for rapid setting/curing, suitable mechanical supporting, good biocompatibility, and sustainable growth factor delivery. Meanwhile, graphene mesh can improve the toughness of conduit and enhance conductivity of conduit for regeneration. Here, novel silk tapes show quick and tough adhesion of wet tissue by dual mechanism to replace suture step. The in vivo results demonstrate that gradient concentration of netrin-1 in conduit have better performance than uniform concentration caused by chemotaxis phenomenon for axon extension, remyelination, and angiogenesis. Altogether, GelMA/silk graphene conduit with gradient netrin-1 and dry double-sided adhesive tape can significantly promote repairing of peripheral nerve injury and inhibit the atrophy of muscles for diabetics.

diabetes growth factor gradients nerve guidance conduits non-suture peripheral nerve regeneration

SCI ; EI

英语

第一 ; 通讯

RGC[16304421] ; Innovation and Technology Commission["ITC-CNERC14SC01","MHP/046/20"] ; Guangdong Science and Technology Department[2020A0505090003] ; Research Fund of Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology[2020B1212030010] ; Shenzhen Special Fund for Central Guiding the Local Science and Technology Development[2021Szvup136] ; IER foundation[HT-JD-CXY-201907] ; "International Science and Technology Cooperation Projects" of Science and Technological Bureau of Guangzhou Huangpu District[2019GH06] ; National Natural Science Foundation of China[81971758,51890892,81971712,81870346,81700432,82070449] ; Natural Science Foundation of Shanghai Science and Technology Committee[20ZR1431600] ; Guangdong Provincial Key Laboratory Program from the Department of Science and Technology of Guangdong Province[2021B1212040001]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000813882000001

WILEY

20222512250349

Adhesives ; Biochemistry ; Biocompatibility ; Hydrogels ; Noninvasive medical procedures ; Repair

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Nanotechnology:761 ; Biochemistry:801.2 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Maintenance:913.5

Web of Science

1.Southern Univ Sci & Technol, Guangdong Prov Key Lab Funct Oxide Mat & Devices, Shenzhen 518055, Guangdong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Guangdong Hong Kong Macao Joint Lab Intelligent M, William Mong Inst Nano Sci & Technol,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
3.Hong Kong Univ Sci & Technol, Hong Kong Branch, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Vasc Surg, Shanghai 200011, Peoples R China
5.Shanghai Jiao Tong Univ, Vasc Ctr, Shanghai 200011, Peoples R China
6.Korea Adv Inst Sci & Technol KAIST, KAIST Inst Nanocentury, Dept Mat Sci & Engn, Daejeon 34141, South Korea
7.Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr BEBC, Xian 710049, Peoples R China
8.Guangzhou Baiyun Med Adhes Co Ltd, Guangzhou 510405, Guangdong, Peoples R China
9.Silver Age Engn Plast Dongguan Co Ltd, Dongguan 523187, Guangdong, Peoples R China

Cai, Yuting,Huang, Qun,Wang, Penghui,et al. Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape[J]. Advanced Healthcare Materials,2022,11.

Cai, Yuting.,Huang, Qun.,Wang, Penghui.,Ye, Kaichuang.,Zhao, Zhen.,...&Luo, Zhengtang.(2022).Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape.Advanced Healthcare Materials,11.

Cai, Yuting,et al."Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non-Suture Tape".Advanced Healthcare Materials 11(2022).