The Roles of Adipose Tissue Macrophages in Human Disease

Liang, Weizheng1,2; Qi, Yanxu3,9,10; Yi, Hongyang4,11; Mao, Chenyu5; Meng, Qingxue1; Wang, Hao6,7; Zheng, Chunfu2,8

2022-06-09

10.3389/fimmu.2022.908749

Frontiers in Immunology   影响因子和分区

1664-3224

Macrophages are a population of immune cells functioning in antigen presentation and inflammatory response. Research has demonstrated that macrophages belong to a cell lineage with strong plasticity and heterogeneity and can be polarized into different phenotypes under different microenvironments or stimuli. Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation. Previous studies have indicated that adipose tissue macrophages (ATMs) are closely related to metabolic diseases like obesity and diabetes. Here, we will not only conclude the current progress of factors affecting the polarization of adipose tissue macrophages but also elucidate the relationship between ATMs and human diseases. Furthermore, we will highlight its potential in preventing and treating metabolic diseases as immunotherapy targets.

Adipose tissue macrophages inflammation obesity diabetes insulin resistance (IR) insulin sensitivity (IS)

SCI

英语

其他

Natural Science Foundation of Shandong Province["ZR2020MH190","ZR2021MH086"] ; Medical Science and Technology Development Plans of Shandong province[202008021019] ; Project of Department of education of Guangdong province[2021KQNCX074]

Immunology

Immunology

WOS:000814856100001

FRONTIERS MEDIA SA

Web of Science

1.Hebei North Univ, Cent Lab, Affiliated Hosp 1, Zhangjiakou, Peoples R China
2.Fujian Med Univ, Sch Basic Med Sci, Dept Immunol, Fuzhou, Peoples R China
3.Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Jinan, Peoples R China
4.Third Peoples Hosp Shenzhen, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
5.Univ Penn, Sch Engn & Appl Sci, Philadelphia, PA USA
6.Shenzhen Univ, Shenzhen Key Lab, Gen Hosp, Shenzhen, Peoples R China
7.Shenzhen Univ, Dept Obstet & Gynecol, Gen Hosp, Shenzhen, Peoples R China
8.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada
9.Shandong Key Lab Oral Tissue Regenerat, Jinan, Peoples R China
10.Shandong Engn Lab Dent Mat & Oral Tissue Regenerat, Jinan, Peoples R China
11.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Peoples R China

Liang, Weizheng,Qi, Yanxu,Yi, Hongyang,et al. The Roles of Adipose Tissue Macrophages in Human Disease[J]. Frontiers in Immunology,2022,13.

Liang, Weizheng.,Qi, Yanxu.,Yi, Hongyang.,Mao, Chenyu.,Meng, Qingxue.,...&Zheng, Chunfu.(2022).The Roles of Adipose Tissue Macrophages in Human Disease.Frontiers in Immunology,13.

Liang, Weizheng,et al."The Roles of Adipose Tissue Macrophages in Human Disease".Frontiers in Immunology 13(2022).