南方科技大学知识苑(SUSTech KC): The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China

题名	The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China
作者	Huang，Wei 1; Fang，Zhixiong 2; Luo，Si 3; Lin，Sha 2; Xu，Lei 2; Yan，Bo 1; yang，Yang 1; Liu，Xuhui 1; Xia，Lu 1; Fan，Xiaoyong 1; Lu，Shuihua 4
通讯作者	Lu，Shuihua
发表日期	2022-09-01
DOI	10.1016/j.ijid.2022.06.010
发表期刊	INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 影响因子和分区
ISSN	1201-9712
EISSN	1878-3511
卷号	122页码:321-326
摘要	Objectives: In this study, we aimed to verify whether Bacillus Calmette–Guérin (BCG) can protect first-year college students against Mycobacterium tuberculosis (MTB) infection by the recombinant fusion protein ESAT6-CFP10 skin test (ECST) or the tuberculin skin test (TST). Methods: We conducted a cross-sectional study to assess risk factors for latent tuberculosis infection (LTBI). Vaccine effectiveness of BCG against LTBI, measured by ECST and TST separately, was assessed using multivariable logistic regression. Results: A total of 7351 college freshmen accepted ECST, whereas 7228 accepted TST. A total of 263 (3.58%) tested positive with ECST and 581 (8.04%) tested positive with TST. BCG was significantly associated with LTBI (ECST: adjusted odds ratio (aOR) = 0.26; 95% CI 0.09 to 0.73; TST: aOR = 0.25; 95% CI 0.13 to 0.49). The BCG protective effect on freshmen living in rural areas (ECST: aOR = 0.16; 95% CI 0.04 to 0.55; TST: aOR = 0.12; 95% CI 0.04 to 0.33) is better than that of freshmen living in cities (ECST: aOR = 0.53; 95% CI 0.07 to 4.03; TST: aOR = 0.44; 95% CI 0.17 to 1.16). Conclusions: Protection against LTBI was strongly associated with BCG vaccination. A novel skin test (ECST) may underestimate the protective effects of BCG in college freshmen. BCG has better protection in areas with a slightly higher incidence of LTBI.
关键词	BCG vaccine ECST Mycobacterium tuberculosis infection TST Vaccine effectiveness
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Hunan Province Science and Tech-nology Major project[20200855]
WOS研究方向	Infectious Diseases
WOS类目	Infectious Diseases
WOS记录号	WOS:000836319700016
出版者	ELSEVIER SCI LTD
ESI学科分类	IMMUNOLOGY
Scopus记录号	2-s2.0-85132726703
来源库	Scopus
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/352475
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Department of Pulmonary Medicine,Shanghai Public Health Clinical Center,Shanghai,China 2.Department of Infectious Disease and Public Health,Central Hospital of Xiangtan,Hunan province,China 3.Xiangtan Center for Disease Control and Prevention,Hunan province,China 4.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518112,China
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Huang，Wei,Fang，Zhixiong,Luo，Si,et al. The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China[J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,2022,122:321-326.
APA	Huang，Wei.,Fang，Zhixiong.,Luo，Si.,Lin，Sha.,Xu，Lei.,...&Lu，Shuihua.(2022).The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China.INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES,122,321-326.
MLA	Huang，Wei,et al."The effect of BCG vaccination and risk factors for latent tuberculosis infection among college freshmen in China".INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 122(2022):321-326.