南方科技大学知识苑(SUSTech KC): Cryo-EM studies of the apo states of human IGF1R

题名	Cryo-EM studies of the apo states of human IGF1R
作者	Zhang，Xi1,2,3 ; Wu，Cang 4; Wei，Tianzi4,5 ; Lu，Yi6 ; Liu，Chuang 7; Zhang，Jian6
通讯作者	Lu，Yi; Liu，Chuang; Zhang，Jian
发表日期	2022-08-27
DOI	10.1016/j.bbrc.2022.05.063
发表期刊	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 影响因子和分区
ISSN	0006-291X
EISSN	1090-2104
卷号	618页码:148-152
摘要	IGF1R plays an important role in regulating cellular metabolism and growth. As a single transmembrane protein, its structure is flexible. Although previous studies revealed some structures of IGF1R, the cryo-EM apo structures of the receptor have never been reported. Herein, we reported four distinct cryo-EM structures that reveal the apo states of IGF1R. These conformations were classified as “Resting states” and “Active states”, according to the orientation of α-CT helices and structural symmetry. In addition, a “Ligand-pocket” was formed in the active conformations, which presented a new view of conformational changes of apo-IGF1R. These results suggest a new dynamic change model to show the details of why and how ligands can bind to IGF1R.
关键词	Apo-IGF1R Conformation change Cryo-EM
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Natural Science Foundation of China[31900868];National Natural Science Foundation of China[81972766];National Natural Science Foundation of China[JCYJ20170412152943794];National Natural Science Foundation of China[JCYJ20170412154619484];National Natural Science Foundation of China[JCYJ20200109141638004];
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:000878139200002
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85132739372
来源库	Scopus
引用统计	被引频次[WOS]：3
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/352476
专题	生命科学学院_生物系生命科学学院南方科技大学医学院
作者单位	1.Department of Gastroenterology,The First Affiliated Hospital of Shenzhen University,Shenzhen People's Second Hospital,Shenzhen,Guangdong,518000,China 2.Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong,518055,China 3.Cryo-EM Centre,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 4.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 5.School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong SAR, Hong Kong SAR,999077,Hong Kong 6.School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 7.Centre for PanorOmic Sciences,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong SAR, Hong Kong SAR,999077,Hong Kong
第一作者单位	南方科技大学
通讯作者单位	南方科技大学医学院
推荐引用方式 GB/T 7714	Zhang，Xi,Wu，Cang,Wei，Tianzi,et al. Cryo-EM studies of the apo states of human IGF1R[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2022,618:148-152.
APA	Zhang，Xi,Wu，Cang,Wei，Tianzi,Lu，Yi,Liu，Chuang,&Zhang，Jian.(2022).Cryo-EM studies of the apo states of human IGF1R.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,618,148-152.
MLA	Zhang，Xi,et al."Cryo-EM studies of the apo states of human IGF1R".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 618(2022):148-152.