六、七元硅中心手性杂环的不对称合成

  硅中心手性硅烷是一类重要的化合物，在手性药物和新型功能材料方面有潜在应用。手性硅烷主要通过手性辅剂拆分、动力学拆分和不对称催化等方法得到。毫无疑问，利用过渡金属不对称催化一步构建结构多样的硅中心手性硅烷是更高效、更原子经济的方法。在此前的工作中，通过对二氢硅烷和四取代硅烷的去对称化，可以实现硅中心手性硅烷的合成。其中，含硅中心手性五元硅环的合成方法较为丰富，而六元和七元环的例子很少。

  基于以上几点，我们通过合理的底物设计实现了一系列六元、七元环的三取代硅中心手性杂环化合物的构建。该过程经历了铑催化分子内直接脱氢的C–H硅基化反应，具有良好的产率、优异的对映选择性和广泛的底物普适性等优点。再者，通过对产物一氢硅烷进一步转化，可以得到手性保持的相应四取代硅中心手性硅烷。通过该方法，我们可以快速地构建含硅中心手性的π-共轭联芳烃骨架。更重要的是，大部分产物表现出明亮的蓝色荧光性质。其中，某些产物展现出圆偏振发光的特性，这为手性硅基功能材料的发展提供了新思路。

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