Hybrid ceramics-based cancer theranostics

Guan, Qingwen1,2; He, Binbin2; Huang, Jie3; Lu, Helen H.4; Wang, Min1

2022-06-01

10.1007/s43207-022-00217-w

Journal of the Korean Ceramic Society   影响因子和分区

1229-7801

2234-0491

Cancer is a major threat to human lives. Early detection and precisely targeted therapy/therapies for cancer is the most effective way to reduce the difficulties (e.g., side effects, low survival rate, etc.) in treating cancer. To enable effective cancer detection and treatment, ceramic biomaterials have been intensively and extensively investigated owing to their good biocompatibility, high bioactivity, suitable biodegradability and other distinctive properties that are required for medical devices in oncology. Through hybridization with other materials and loading of imaging agents and therapeutic agents, nanobioceramics can form multifunctional nanodevices to simultaneously provide diagnostic and therapeutic functions for cancer patients, and these nanodevices are known as hybrid ceramics-based cancer theranostics. In this review, the recent developments of hybrid ceramics-based cancer theranostics, which include the key aspects such as their preparation, biological evaluation and applications, are summarized and discussed. The challenges and future perspectives for the clinical translation of hybrid ceramics-based cancer theranostics are also discussed. It is believed that the potential of hybrid ceramic nanoparticles as cancer theranostics is high and that the future of these theranostics is bright despite the difficulties along the way for their clinical translation.

Cancer Detection Therapy Theranostics Multifunctional Bioceramics Calcium phosphate Silica Bioactive glass Clinical

SCI ; EI

英语

其他

Materials Science

Materials Science, Ceramics

WOS:000813735900001

SPRINGER HEIDELBERG

20222612267795

Bioactive glass ; Bioceramics ; Biocompatibility ; Biodegradability ; Calcium phosphate ; Diagnosis ; Diseases ; Hybrid materials ; Nanostructured materials

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Biomaterials (including synthetics):462.5 ; Minerals:482.2 ; Nanotechnology:761 ; Biochemistry:801.2 ; Inorganic Compounds:804.2 ; Ceramics:812.1 ; Glass:812.3 ; Crystalline Solids:933.1

Web of Science

1.Univ Hong Kong, Dept Mech Engn, Pokfulam Rd, Hong Kong, Peoples R China
2.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen, Peoples R China
3.UCL, Dept Mech Engn, Torrington Pl, London, England
4.Columbia Univ, Dept Biomed Engn, 1210 Amsterdam Ave, New York, NY 10027 USA

Guan, Qingwen,He, Binbin,Huang, Jie,et al. Hybrid ceramics-based cancer theranostics[J]. Journal of the Korean Ceramic Society,2022,59:401-426.

Guan, Qingwen,He, Binbin,Huang, Jie,Lu, Helen H.,&Wang, Min.(2022).Hybrid ceramics-based cancer theranostics.Journal of the Korean Ceramic Society,59,401-426.

Guan, Qingwen,et al."Hybrid ceramics-based cancer theranostics".Journal of the Korean Ceramic Society 59(2022):401-426.