Effect of Chain Lengths on the Antibiofilm and Hemolytic Activities of Main-Chain Alternating Polysulfoniums

Hu, Yongjin1; Zhao, Jinghua2,3,4; Yang, Mingdi1; Wang, Xianbiao1; Zhang, Haijiang5; Zhang, Jingyan1; Zhu, Zhiyuan6,7; Rao, Jingyi2,3,4

2022-06-01

10.1021/acsapm.2c00463

ACS Applied Polymer Materials   影响因子和分区

2637-6105

Unlike antibiotics with accurate chemical structures, polydisperse chain lengths of synthetic polycations usually result in undesirable variations of antibacterial performance, which obstructs their wide applications in many areas. Herein, we propose that mainchain sulfonium-based polymers with alternating sequences may be used as a potential solution to tackle this issue. Through the thiol- epoxy "click" step-growth polymerization and methylation, alternating polysulfoniums can be facilely prepared with polydispersity around 1.5 and a molecular weight ranging from 6000 to 50 000 g/mol. Within this tested range, constant minimum bactericidal concentration (MBC) values against a broad spectrum of clinically relevant bacteria and stable hemocompatibility are observed for polysulfoniums with different chemical compositions. Moreover, the representative polysulfonium can steadily inhibit the biofilm formation (similar to 75- 90%) at 1.25-5 mu g/mL and achieve 97-99.9% reduction of bacteria at 10-40 mu g/mL in the 3 day mature biofilms. We hypothesize that the amphiphilicity of main-chain polysulfoniums displays less susceptibility to the dispersed polymer chains, probably because of their accurate alternating sequence and the location of all functional groups in the polymer main chain. The unique structural nature of the main-chain sulfonium-based alternating polymers can make them serve as a reliable platform for antibacterial applications in the field of synthetic polycations.

antibacterial antibiofilm alternating copolymers polysulfoniums

SCI ; EI

英语

非南科大

National Natural Science Foundation of China[52003096,21976003,21004001] ; Fundamental Research Funds for the Central Universities[2020kfyXJJS061] ; Anhui Jianzhu University[2020QDZ06]

Materials Science ; Polymer Science

Materials Science, Multidisciplinary ; Polymer Science

WOS:000819519600001

AMER CHEMICAL SOC

20223012400901

Alkylation ; Bacteria ; Biofilms ; Polydispersity

Biomaterials (including synthetics):462.5 ; Physical Chemistry:801.4 ; Chemical Reactions:802.2 ; Polymers and Polymer Science:815 ; Atomic and Molecular Physics:931.3

Web of Science

1.Anhui Jianzhu Univ, Sch Mat & Chem Engn, Hefei 230601, Anhui, Peoples R China
2.Huazhong Univ Sci & Technol, Hubei Key Lab Mat Chem & Serv Failure, Wuhan 430074, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Hubei Engn Res Ctr Biomat & Med Protect Mat, Wuhan 430074, Hubei, Peoples R China
4.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Hubei, Peoples R China
5.Univ Gothenburg, Sahlgrenska Acad, Ctr Cellular Imaging, Core Facil, S-41390 Gothenburg, Sweden
6.Suzhou Jufeng Elect Insulat Syst Co Ltd, Suzhou 215214, Jiangsu, Peoples R China
7.Southern Univ Sci & Technol, Taizhou Res Inst, Res Ctr Comprehens Prevent & Control Environm Pol, Taizhou 318001, Zhejiang, Peoples R China

Hu, Yongjin,Zhao, Jinghua,Yang, Mingdi,et al. Effect of Chain Lengths on the Antibiofilm and Hemolytic Activities of Main-Chain Alternating Polysulfoniums[J]. ACS Applied Polymer Materials,2022,4:4868-4875.

Hu, Yongjin.,Zhao, Jinghua.,Yang, Mingdi.,Wang, Xianbiao.,Zhang, Haijiang.,...&Rao, Jingyi.(2022).Effect of Chain Lengths on the Antibiofilm and Hemolytic Activities of Main-Chain Alternating Polysulfoniums.ACS Applied Polymer Materials,4,4868-4875.

Hu, Yongjin,et al."Effect of Chain Lengths on the Antibiofilm and Hemolytic Activities of Main-Chain Alternating Polysulfoniums".ACS Applied Polymer Materials 4(2022):4868-4875.