The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer

Chiang, Chengyao1,2; Yang, Heng2; Zhu, Lizhi2; Chen, Chunlan2; Chen, Cheng2; Zuo, You1; Zheng, Duo2

2022-06-22

10.3389/fgene.2022.918509

FRONTIERS IN GENETICS   影响因子和分区

1664-8021

Epigenetic modifications are essential mechanism by which to ensure cell homeostasis. One such modification is lysine methylation of nonhistone proteins by SETD7, a mono-methyltransferase containing SET domains. SETD7 methylates over 30 proteins and is thus involved in various classical pathways. As such, SETD7 has been implicated in both the basic functions of normal tissues but also in several pathologies, such as cancers. In this review, we summarize the current knowledge of SETD7 substrates, especially transcriptional-related proteins and enzymes, and their putative roles upon SETD7-mediated methylation. We focus on the role of SETD7 in cancers, and speculate on the possible points of intervention and areas for future research.

SETD7 epigentics non-histone substrate transcriptional factor protein methylaiton

SCI

英语

第一 ; 通讯

Genetics & Heredity

Genetics & Heredity

WOS:000822575600001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Yantian Hosp, Shenzhen, Peoples R China
2.Shenzhen Univ, Shenzhen Univ Int Canc Ctr, Affiliated Hosp Shenzhen Univ 1, Shenzhen Peoples Hosp 2,Shenzhen Inst Translat Med, Shenzhen, Peoples R China

Chiang, Chengyao,Yang, Heng,Zhu, Lizhi,et al. The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer[J]. FRONTIERS IN GENETICS,2022,13.

Chiang, Chengyao.,Yang, Heng.,Zhu, Lizhi.,Chen, Chunlan.,Chen, Cheng.,...&Zheng, Duo.(2022).The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer.FRONTIERS IN GENETICS,13.

Chiang, Chengyao,et al."The Epigenetic Regulation of Nonhistone Proteins by SETD7: New Targets in Cancer".FRONTIERS IN GENETICS 13(2022).