南方科技大学知识苑(SUSTech KC): Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes

题名	Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes
作者	Chen, Chi 1; Bin Wang 1; Zhang, Haojie 1; Wang, Yuying 1; Yu, Shiyan 2; Zhou, Shuo 3; Chen, Yi 1; Xia, Fangzhen 1; Zhai, Hualing 1; Wang, Ningjian 4; Lu, Yingli 1
通讯作者	Zhai, Hualing; Wang, Ningjian; Lu, Yingli
发表日期	2022-07-01
DOI	10.1007/s12011-022-03357-6
发表期刊	BIOLOGICAL TRACE ELEMENT RESEARCH 影响因子和分区
ISSN	0163-4984
EISSN	1559-0720
卷号	201 期号:5页码:2266-2273
摘要	We aimed to explore whether an elevated blood lead level (BLL) is associated with visceral adipose dysfunction in patients with type 2 diabetes mellitus (T2DM). Four thousand one hundred and fourteen diabetic participants were enrolled from seven communities in Shanghai in 2018 in the cross-sectional METAL study. BLL was measured by graphite furnace atomic absorption spectrometry. Visceral adiposity index (VAI) and lipid accumulation product (LAP)were calculated by simple anthropometric and biochemical parameters. We found that medians (IQR) of BLL were 26.0 mu g/L (18.0-37.0) for men and 25.0 mu g/L (18.0-35.0) for women, respectively. In men, each doubling of BLL was associated with a 2.0% higher VAI (95% CI, 0.6 to 3.5%) and 1.8% higher LAP (95% CI, 0.2 to 3.3%) after full adjustment. Using the lowest BLL quartile as the referent group, significant positive trends were observed for BLL with VAI and LAP. In women, each doubling of BLL was associated with a 1.9% higher LAP (95% CI, 0.6 to 3.1%). Additionally, there was a marginally significant positive association between BLL and VAI, either using log2-transformed concentrations as continuous variables or categorized in quartiles. In conclusion, lead exposure is associated with visceral adipose dysfunction in patients with T2DM. Further prospective studies are warranted to confirm our findings.
关键词	Lead Visceral adipose dysfunction Type 2 diabetes mellitus Epidemiology
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China["82100846","82170870","82120108008"] ; Shanghai Sailing Program[20YF1423500] ; Science and Technology Commission of Shanghai Municipality[19140902400] ; Clinical Research Plan of SHDC[SHDC2020CR4006]
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000826788000001
出版者	SPRINGERNATURE
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85134504345
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/356165
专题	南方科技大学第一附属医院
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst & Dept Endocrinol & Metab, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China 2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Inst Precis Med, Sch Med, Shanghai, Peoples R China 3.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Anesth, Shenzhen, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Endocrinol & Metab, Huangpu Branch,Sch Med, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Chen, Chi,Bin Wang,Zhang, Haojie,et al. Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes[J]. BIOLOGICAL TRACE ELEMENT RESEARCH,2022,201(5):2266-2273.
APA	Chen, Chi.,Bin Wang.,Zhang, Haojie.,Wang, Yuying.,Yu, Shiyan.,...&Lu, Yingli.(2022).Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes.BIOLOGICAL TRACE ELEMENT RESEARCH,201(5),2266-2273.
MLA	Chen, Chi,et al."Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes".BIOLOGICAL TRACE ELEMENT RESEARCH 201.5(2022):2266-2273.