Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria

Zhao, Xiaohui; Tang, Hao; Jiang, Xingyu

2022-07-01

10.1021/acsnano.2c02269

ACS Nano   影响因子和分区

1936-0851

1936-086X

Antibiotic resistance has become a serious threat to human health due to the overuse of antibiotics. Different antibiotics are being developed to treat resistant bacteria, but the development cycle of antibiotics is hard to keep up with the high incidence of antibiotic resistance. Recent advances in antimicrobial nanomaterials have made nanotechnology a powerful solution to this dilemma. Among these nanomaterials, gold nanomaterials have excellent antibacterial efficacy and biosafety, making them alternatives to antibiotics. This review presents strategies that use gold nanomaterials to combat drug-resistant bacteria. We focus on the influence of physicochemical factors such as surface chemistry, size, and shape of gold nanomaterials on their antimicrobial properties and describe the antimicrobial applications of gold nanomaterials in medical devices. Finally, the existing challenges and future directions are discussed.

multi-drug-resistant bacteria gold nanoantibiotics surface modification structure-activity relationship biosafety wound dressing implantable devices clinical translation

SCI ; EI

英语

第一 ; 通讯

National Key R&D Program of China[2018YFA0902600] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000824704700001

AMER CHEMICAL SOC

20223012418055

Bacteria ; Biohazards ; Gold ; Health risks ; Implants (surgical) ; Nanostructured materials ; Physicochemical properties ; Surface chemistry

Medicine and Pharmacology:461.6 ; Health Care:461.7 ; Prosthetics:462.4 ; Precious Metals:547.1 ; Nanotechnology:761 ; Physical Chemistry:801.4 ; Accidents and Accident Prevention:914.1 ; Crystalline Solids:933.1

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Guangdong, Peoples R China

Zhao, Xiaohui,Tang, Hao,Jiang, Xingyu. Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria[J]. ACS Nano,2022,16:10066-10087.

Zhao, Xiaohui,Tang, Hao,&Jiang, Xingyu.(2022).Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria.ACS Nano,16,10066-10087.

Zhao, Xiaohui,et al."Deploying Gold Nanomaterials in Combating Multi-Drug-Resistant Bacteria".ACS Nano 16(2022):10066-10087.