Mild Amide Synthesis Using Nitrobenzene under Neutral Conditions

Xiong, Ni1; Dong, Yuanqi1; Xu, Bin1; Li, Yang1; Zeng, Rong1,2

2022-06-01

10.1021/acs.orglett.2c01743

ORGANIC LETTERS   影响因子和分区

1523-7060

1523-7052

ABSTRACT: Amide synthesis is one of the most important transformations in organic chemistry due to the broad application in pharmaceutical drugs and organic materials. In this report, we describe a mild protocol for amide formation using the readily available nitroarenes as nitrogen sources and an inexpensive iron complex as a catalyst. Because of the use of the pH-neutral conditions and the avoidance of the strong oxidant or reductant, a wide range of aromatic and aliphatic aldehydes as well as nitroarenes with various functional groups could be tolerated well. A plausible mechanism is proposed based on the detailed studies, in which iron catalyst initiates the radical process and the solvent plays a key role as O-atom acceptor.

SCI

英语

NI论文

通讯

Chemistry

Chemistry, Organic

WOS:000821932100001

AMER CHEMICAL SOC

CHEMISTRY

Web of Science

1.Xi An Jiao Tong Univ, Sch Chem, Xian 710049, Peoples R China
2.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China

Xiong, Ni,Dong, Yuanqi,Xu, Bin,et al. Mild Amide Synthesis Using Nitrobenzene under Neutral Conditions[J]. ORGANIC LETTERS,2022.

Xiong, Ni,Dong, Yuanqi,Xu, Bin,Li, Yang,&Zeng, Rong.(2022).Mild Amide Synthesis Using Nitrobenzene under Neutral Conditions.ORGANIC LETTERS.

Xiong, Ni,et al."Mild Amide Synthesis Using Nitrobenzene under Neutral Conditions".ORGANIC LETTERS (2022).