| 题名 | Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles |
| 作者 | |
| 通讯作者 | Li Pengfei; Qi Yunkun; Li Wenjun |
| 发表日期 | 2022-03-08
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| DOI | |
| 发表期刊 | |
| ISSN | 0253-2786
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| 卷号 | 42期号:6页码:1722-1734 |
| 摘要 | A chiral phosphoric acid catalyzed aza-1,8-conjugate addition of isoxazol-5(4H)-ones to 6-methylene-6H-indoles formed in situ from 6-indolylmethanols has been developed for the first time. Notably, the remote stereocontrolled 1,8-addition of isoxazol-5(4H)-ones was featured by N-selectivity, affording aza-adducts in 70%similar to 83% yields with 61%similar to 96% ee. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 中文
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| 学校署名 | 通讯
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| 资助项目 | Natural Science Foundation of Shandong Province[ZR2021MB026]
; Special Funds of the Taishan Scholar Program of Shandong Province[tsqn201812047]
; Shenzhen Innovation of Science and Technology Commission[20200925151614002]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
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| WOS研究方向 | Chemistry
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| WOS类目 | Chemistry, Organic
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| WOS记录号 | WOS:000826720300013
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| 出版者 | |
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：6
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/356202 |
| 专题 | 深圳格拉布斯研究院 理学院_化学系 |
| 作者单位 | 1.Qingdao Univ, Sch Pharm, Qingdao 266073, Shandong, Peoples R China 2.South Univ Sci & Technol China, Coll Sci, Shenzhen Grubbs Inst, Guangzhou 518055, Peoples R China 3.South Univ Sci & Technol China, Coll Sci, Dept Chem, Guangdong Prov Key Lab Catalysis, Guangzhou 518055, Peoples R China |
| 通讯作者单位 | 深圳格拉布斯研究院; 化学系 |
| 推荐引用方式 GB/T 7714 |
Wang Xing,Song Qianqian,Chen Xuling,et al. Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2022,42(6):1722-1734.
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| APA |
Wang Xing,Song Qianqian,Chen Xuling,Li Pengfei,Qi Yunkun,&Li Wenjun.(2022).Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles.CHINESE JOURNAL OF ORGANIC CHEMISTRY,42(6),1722-1734.
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| MLA |
Wang Xing,et al."Organocatalytic Regio- and Enantioselective aza-1,8-Conjugate Additions of Isoxazol-5(4H)-ones to 6-Methide-6H-indoles".CHINESE JOURNAL OF ORGANIC CHEMISTRY 42.6(2022):1722-1734.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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