南方科技大学知识苑(SUSTech KC): IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma

题名	IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma
作者	Liu, Hongmei1,2 ; Gao, Huan 3; Chen, Cheng 3; Jia, Wenyu 3; Xu, Delong 3; Jiang, Guan 1,3
通讯作者	Jiang, Guan
发表日期	2022-07-01
DOI	10.3389/fonc.2022.904229
发表期刊	Frontiers in Oncology 影响因子和分区
ISSN	2234-943X
卷号	12
摘要	In this study, we synthesized a molecule GA-1MT (GM) composed of indoleamine 2,3-dioxygenase (IDO) inhibitor (1-methyl-d-tryptophan, 1MT) called NLG8189 and gallic acid (GA) and verified its therapeutic effect on B16F10 melanoma cells and an orthotopic tumor-bearing mouse model. The synthesized molecule GM was analyzed by H-1 NMR and mass spectrometry (MS). In addition, we confirmed that GM could mediate the immune response in the B16F10 cell tumor model by flow cytometry and immunofluorescence. The synthesized GM molecule could increase the solubility of 1MT to enhance the drug efficacy and lower costs. Moreover, GM could inhibit melanoma growth by combining 1MT and GA. In vivo experiments showed that GM could effectively inhibit the expression of tyrosinase, regulate the proportion of CD4(+) T cells, CD8(+) T cells, and regulatory T cells (T-reg cells) in tumors, and significantly suppress melanoma growth. The newly synthesized drug GM could more effectively inhibit melanoma than GA and 1MT alone or in combination.
关键词	gallic acid indoleamine 2 3-dioxygenase melanoma chemotherapy immunotherapy
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:000829827800001
出版者	FRONTIERS MEDIA SA
来源库	Web of Science
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/359470
专题	工学院_生物医学工程系
作者单位	1.Xuzhou Med Univ, Xuzhou, Peoples R China 2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China 3.Xuzhou Med Univ, Affiliated Hosp, Dept Dermatol, Xuzhou, Peoples R China
第一作者单位	生物医学工程系
推荐引用方式 GB/T 7714	Liu, Hongmei,Gao, Huan,Chen, Cheng,et al. IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma[J]. Frontiers in Oncology,2022,12.
APA	Liu, Hongmei,Gao, Huan,Chen, Cheng,Jia, Wenyu,Xu, Delong,&Jiang, Guan.(2022).IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma.Frontiers in Oncology,12.
MLA	Liu, Hongmei,et al."IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma".Frontiers in Oncology 12(2022).