题名 | Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples |
作者 | |
通讯作者 | Zhang,Zheng; Wang,Fuxiang; Wei,Lanlan |
发表日期 | 2022-07-08
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DOI | |
发表期刊 | |
ISSN | 1664-3224
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EISSN | 1664-3224
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卷号 | 13 |
摘要 | Molecular assays on nasopharyngeal swabs act as a confirmatory test in coronavirus disease (COVID-19) diagnosis. However, the technical requirements of nasopharyngeal sampling and molecular assays limit the testing capabilities. Recent studies suggest the use of saliva for the COVID-19 diagnostic test. In this study, 44 patients diagnosed with COVID-19 in The Third People’s Hospital of Shenzhen were enrolled. Saliva and serum specimens were obtained at different time points and the immunoglobulins against SARS-CoV-2 were measured. The results showed that saliva IgA presented a higher COI value than IgG and IgM. In matched saliva and serum samples, all saliva samples presented lower IgG levels than serum samples, and only one saliva sample presented a higher IgM level. The conversion rates of saliva IgA and the detection of viral nucleic acids were analyzed in the first and second weeks after hospitalization. The positive rates increased when combining saliva IgA and viral nucleic acid detection. In conclusion, our results provide evidence that saliva IgA could serve as a useful index for the early diagnosis of COVID-19. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 其他
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资助项目 | [SZGSP010]
; [SZGSP011]
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WOS研究方向 | Immunology
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WOS类目 | Immunology
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WOS记录号 | WOS:000890909000001
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出版者 | |
Scopus记录号 | 2-s2.0-85134712234
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来源库 | Scopus
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引用统计 |
被引频次[WOS]:5
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/359557 |
专题 | 南方科技大学医学院 |
作者单位 | 1.Institute of Hepatology,National Clinical Research Center for Infectious Disease,The Third People’s Hospital of Shenzhen,The Second Hospital Affiliated to Southern,University of Science and Technology,Shenzhen,China 2.Clinical Laboratory,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen,China 3.Department of Infectious Diseases,The Third People’s Hospital of Shenzhen,The Second Hospital Affiliated to Southern,University of Science and Technology,Shenzhen,China 4.School of Medicine,Southern University of Science and Technology,Shenzhen,China 5.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,China |
推荐引用方式 GB/T 7714 |
Yu,Siyang,Zhang,Peiyan,Liao,Mingfeng,et al. Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples[J]. Frontiers in Immunology,2022,13.
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APA |
Yu,Siyang.,Zhang,Peiyan.,Liao,Mingfeng.,Zhang,Juanjuan.,Luo,Suisui.,...&Wei,Lanlan.(2022).Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples.Frontiers in Immunology,13.
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MLA |
Yu,Siyang,et al."Detection of SARS-CoV-2 Specific Antibodies in Saliva Samples".Frontiers in Immunology 13(2022).
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条目包含的文件 | 条目无相关文件。 |
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