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题名

Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2

作者
通讯作者Ma,Baode; Zhang,Xumu
发表日期
2022-06-24
DOI
发表期刊
EISSN
2666-5549
卷号3期号:3
摘要

A highly efficient and enantioselective method for the asymmetric reductive amination of β-keto phosphine derivatives was disclosed, and the corresponding β-amino phosphine oxides could be obtained in high yields (up to 97% yield) and excellent enantioselectivities (up to 97% ee). Moreover, the reaction worked well on a gram scale, indicating that our protocol has potential applications in the synthesis of chiral ligands and organocatalysts.

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相关链接[Scopus记录]
收录类别
语种
英语
学校署名
第一 ; 通讯
资助项目
National Natural Science Foundation of China[21901107] ; National Natural Science Foundation of China["21901107","2020B010188001","2022B1515020055"] ; Shenzhen Bay Laboratory[22171129] ; Shenzhen Science and Technology Innovation Committee["22001113","2020KCXTD016"] ; Key-Area Research and Development Program of Guangdong Province[SZBL2019062801006] ; Stable Support Plan Program of Shenzhen Science and Technology Innovation Committee[KQTD20150717103157174] ; Innovative Team of Universities in Guangdong Province[JCYJ20210324104202007] ; Guangdong Basic and Applied Basic Research Foundation[20200925161222002]
WOS研究方向
Chemistry
WOS类目
Chemistry, Multidisciplinary
WOS记录号
WOS:001025341600001
出版者
来源库
Web of Science
引用统计
被引频次[WOS]:8
成果类型期刊论文
条目标识符http://sustech.caswiz.com/handle/2SGJ60CL/359574
专题理学院_化学系
前沿与交叉科学研究院
作者单位
1.Medi-X Pingshan,Guangdong Provincial Key Laboratory of Catalysis,and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518000,China
2.Shenzhen Bay Laboratory,Shenzhen,518132,China
3.Academy for Advanced Interdisciplinary Studies and Southern University of Science and Technology,Shenzhen,518000,China
第一作者单位化学系
通讯作者单位化学系
第一作者的第一单位化学系
推荐引用方式
GB/T 7714
Liu,Yufeng,Wang,Linzhou,Li,Yingjun,et al. Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2[J]. Green Synthesis and Catalysis,2022,3(3).
APA
Liu,Yufeng,Wang,Linzhou,Li,Yingjun,Ma,Baode,Chen,Gen Qiang,&Zhang,Xumu.(2022).Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2.Green Synthesis and Catalysis,3(3).
MLA
Liu,Yufeng,et al."Highly efficient synthesis of chiral β-amino phosphine derivatives via direct asymmetric reductive amination with ammonium salts and H2".Green Synthesis and Catalysis 3.3(2022).
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