南方科技大学知识苑(SUSTech KC): Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection

题名	Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection
作者	Gao，Xiang1 ; Zhang，Shengyuan 1; Gou，Jizhou 2; Wen，Yanling 1; Fan，Lujie 3; Zhou，Jian 1 ; Zhou，Guangde 2; Xu，Gang 1; Zhang，Zheng 1,4,5
通讯作者	Xu，Gang
发表日期	2022
DOI	10.1016/j.jinf.2022.06.030
发表期刊	JOURNAL OF INFECTION 影响因子和分区
ISSN	0163-4453
EISSN	1532-2742
摘要	The ongoing global pandemic of Coronavirus disease 2019 (COVID-19) poses a serious threat to human health, with patients reportedly suffering from thrombus, vascular injury and coagulation in addition to acute and diffuse lung injury and respiratory diseases. Angiotensin converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 entry, is also an important regulator of renin-angiotensin system (RAS) homeostasis, which plays an unsettled role in the pathogenesis of COVID-19. Here, we demonstrated that SARS-CoV-2 Spike protein activated intracellular signals to degrade ACE2 mRNA. The decrease of ACE2 and higher level of angiotensin (Ang) II were verified in COVID-19 patients. High dose of Ang II induced pulmonary artery endothelial cell death in vitro, which was also observed in the lung of COVID-19 patients. Our finding indicates that the downregulation of ACE2 potentially links COVID-19 to the imbalance of RAS.
关键词	ACE2 Ang II SARS-CoV-2 Spike
相关链接	[Scopus记录]
语种	英语
学校署名	第一 ; 通讯
资助项目	Natural Science Foundation of Guangdong Province[2019A1515011072];National Key Research and Development Program of China[2021YFC2300103];National Science Fund for Distinguished Young Scholars[82025022];National Natural Science Foundation of China[82151212];
ESI学科分类	IMMUNOLOGY
Scopus记录号	2-s2.0-85134557803
来源库	Scopus
引用统计	被引频次[WOS]：27
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/359588
专题	南方科技大学医学院南方科技大学第二附属医院
作者单位	1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518112,China 2.Department for Pathology,Shenzhen Third People's Hospital the Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,China 3.Guangzhou Laboratory,Guangzhou Medical University,Guangzhou,China 4.Guangdong Key laboratory for anti-infection Drug Quality Evaluation,Shenzhen,Guangdong,518112,China 5.Shenzhen Research Center for Communicable Disease Diagnosis,Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong,518112,China
第一作者单位	南方科技大学医学院; 南方科技大学第二附属医院
通讯作者单位	南方科技大学医学院; 南方科技大学第二附属医院
第一作者的第一单位	南方科技大学医学院; 南方科技大学第二附属医院
推荐引用方式 GB/T 7714	Gao，Xiang,Zhang，Shengyuan,Gou，Jizhou,et al. Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection[J]. JOURNAL OF INFECTION,2022.
APA	Gao，Xiang.,Zhang，Shengyuan.,Gou，Jizhou.,Wen，Yanling.,Fan，Lujie.,...&Zhang，Zheng.(2022).Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection.JOURNAL OF INFECTION.
MLA	Gao，Xiang,et al."Spike-mediated ACE2 down-regulation was involved in the pathogenesis of SARS-CoV-2 infection".JOURNAL OF INFECTION (2022).