Digital Light 3D Printed Bioresorbable and NIR-Responsive Devices with Photothermal and Shape-Memory Functions

Pounovic, Nevena1; Marbach, Jessica1; Bao, Yinyin1; Berger, Valentine1; Klein, Karina2; Schleich, Sarah2; Coulter, Fergal Brian3; Kleger, Nicole3; Studart, Andre R.3; Franzen, Daniel4; Luo, Zhi1,5; Leroux, Jean-Christophe1

2022-07-01

10.1002/advs.202200907

ADVANCED SCIENCE   影响因子和分区

2198-3844

Digital light processing (DLP) 3D printing is a promising technique for the rapid manufacturing of customized medical devices with high precision. To be successfully translated to a clinical setting, challenges in the development of suitable photopolymerizable materials have yet to be overcome. Besides biocompatibility, it is often desirable for the printed devices to be biodegradable, elastic, and with a therapeutic function. Here, a multifunctional DLP printed material system based on the composite of gold nanorods and polyester copolymer is reported. The material demonstrates robust near-infrared (NIR) responsiveness, allowing rapid and stable photothermal effect leading to the time-dependent cell death. NIR light-triggerable shape transformation is demonstrated, resulting in a facilitated insertion and expansion of DLP printed stent ex vivo. The proposed strategy opens a promising avenue for the design of multifunctional therapeutic devices based on nanoparticle-polymer composites.

3D printing 4D printing gold nanorods photothermal therapy shape-memory

SCI ; EI

英语

通讯

Swiss National Science Foundation[177178] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000831037800001

WILEY

20223112454946

Biocompatibility ; Cell death ; Digital devices ; Functional polymers ; Infrared devices ; Nanorods

Biology:461.9 ; Immunology:461.9.1 ; Printing Equipment:745.1.1 ; Nanotechnology:761 ; Polymeric Materials:815.1 ; Solid State Physics:933

Web of Science

1.Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland
2.Univ Zurich, Vetsuisse Fac, Musculoskeletal Res Unit, CH-8057 Zurich, Switzerland
3.Swiss Fed Inst Technol, Dept Mat, Complex Mat, CH-8093 Zurich, Switzerland
4.Univ Hosp Zurich, Dept Pulmonol, CH-8006 Zurich, Switzerland
5.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China

Pounovic, Nevena,Marbach, Jessica,Bao, Yinyin,et al. Digital Light 3D Printed Bioresorbable and NIR-Responsive Devices with Photothermal and Shape-Memory Functions[J]. ADVANCED SCIENCE,2022.

Pounovic, Nevena.,Marbach, Jessica.,Bao, Yinyin.,Berger, Valentine.,Klein, Karina.,...&Leroux, Jean-Christophe.(2022).Digital Light 3D Printed Bioresorbable and NIR-Responsive Devices with Photothermal and Shape-Memory Functions.ADVANCED SCIENCE.

Pounovic, Nevena,et al."Digital Light 3D Printed Bioresorbable and NIR-Responsive Devices with Photothermal and Shape-Memory Functions".ADVANCED SCIENCE (2022).