| 题名 | Large-scale genome-wide association study of coronary artery disease in genetically diverse populations |
| 作者 | Tcheandjieu, Catherine1,2,3,4  ; Zhu, Xiang1,5,6,7; Hilliard, Austin T.1; Clarke, Shoa L.1,2; Napolioni, Valerio8,9; Ma, Shining5; Lee, Kyung Min10; Fang, Huaying11; Chen, Fei12; Lu, Yingchang13; Tsao, Noah L.14; Raghavan, Sridharan15,16; Koyama, Satoshi17; Gorman, Bryan R.18,19; Vujkovic, Marijana20,21; Klarin, Derek1,18,22,23,24,25; Levin, Michael G.20,21; Sinnott-Armstrong, Nasa1,11; Wojcik, Genevieve L.26; Plomondon, Mary E.27,28; Maddox, Thomas M.29,30; Waldo, Stephen W.27,28,31; Bick, Alexander G.32; Pyarajan, Saiju18,33; Huang, Jie18,34,35 ; Song, Rebecca18; Ho, Yuk-Lam18; Buyske, Steven36; Kooperberg, Charles37; Haessler, Jeffrey37; Loos, Ruth J. F.38; Do, Ron38,39; Verbanck, Marie38,39,40; Chaudhary, Kumardeep38,39; North, Kari E.41; Avery, Christy L.41; Graff, Mariaelisa41; Haiman, Christopher A.12; Le Marchand, Loic42; Wilkens, Lynne R.42; Bis, Joshua C.43; Leonard, Hampton44,45; Shen, Botong46; Lange, Leslie A.47,48,49; Giri, Ayush50,51; Dikilitas, Ozan52; Kullo, Iftikhar J.52; Stanaway, Ian B.53; Jarvik, Gail P.54,55; Gordon, Adam S.56; Hebbring, Scott57; Namjou, Bahram58,59; Kaufman, Kenneth M.58; Ito, Kaoru17; Ishigaki, Kazuyoshi60; Kamatani, Yoichiro60,61; Verma, Shefali S.62,63; Ritchie, Marylyn D.62,63; Kember, Rachel L.20,64; Baras, Aris65; Lotta, Luca A.65; Kathiresan, Sekar23,66,67,68; Hauser, Elizabeth R.69,70; Miller, Donald R.71,72; Lee, Jennifer S.1,73; Saleheen, Danish20,74; Reaven, Peter D.75,76; Cho, Kelly18,33; Gaziano, J. Michael18,33; Natarajan, Pradeep23,67,77; Huffman, Jennifer E.18; Voight, Benjamin F.20,62,78,79; Rader, Daniel J.21; Chang, Kyong-Mi20,21; Lynch, Julie A.80,81; Damrauer, Scott M.14,20,62; Wilson, Peter W. F.82,83; Tang, Hua11; Sun, Yan, V84,85; Tsao, Philip S.1,73,86; O'Donnell, Christopher J.18,33; Assimes, Themistocles L.1,2,86,87
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| 通讯作者 | Tcheandjieu, Catherine; Assimes, Themistocles L. |
| 发表日期 | 2022-08-01
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| DOI | |
| 发表期刊 | |
| ISSN | 1078-8956
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| EISSN | 1546-170X
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| 摘要 | ["To overcome limitations of previous genome-wide association studies of coronary artery disease, this study incorporates a cohort of individuals containing large fractions of Black and Hispanic individuals to provide a wider view of the genetic landscape of this disease.","We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including nine on the X chromosome, detect eight loci of genome-wide significance in Black and Hispanic individuals, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, in which these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosclerosis performed to date, we find 15 loci of genome-wide significance that robustly overlap with established loci for clinical CAD. Phenome-wide association analyses of novel loci and polygenic risk scores (PRSs) augment signals related to insulin resistance, extend pleiotropic associations of these loci to include smoking and family history, and precisely document the markedly reduced transferability of existing PRSs to Black individuals. Downstream integrative analyses reinforce the critical roles of vascular endothelial, fibroblast, and smooth muscle cells in CAD susceptibility, but also point to a shared biology between atherosclerosis and oncogenesis. This study highlights the value of diverse populations in further characterizing the genetic architecture of CAD."] |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 重要成果 | NI论文
; ESI高被引
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| 学校署名 | 非南科大
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| 资助项目 | Veterans Administration[
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| WOS研究方向 | Biochemistry & Molecular Biology
; Cell Biology
; Research & Experimental Medicine
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| WOS类目 | Biochemistry & Molecular Biology
; Cell Biology
; Medicine, Research & Experimental
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| WOS记录号 | WOS:000834757100001
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| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：109
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/375546 |
| 专题 | 南方科技大学医学院_公共卫生及应急管理学院 |
| 作者单位 | 1.VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA 2.Stanford Univ, Dept Med, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA 3.Gladstone Inst, Gladstone Inst Data Sci & Biotechnol, San Francisco, CA 94158 USA 4.Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA 5.Stanford Univ, Dept Stat, Stanford, CA 94305 USA 6.Penn State Univ, Dept Stat, University Pk, PA 16802 USA 7.Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA 8.Univ Camerino, Sch Biosci & Vet Med, Camerino, Italy 9.Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA 10.VA Salt Lake City Hlth Care Syst, VA Informat & Comp Infrastruct, Salt Lake City, UT USA 11.Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA 12.Univ Southern Calif, Ctr Genet Epidemiol, Dept Prevent Med, Los Angeles, CA USA 13.Vanderbilt Univ Sch Med, Vanderbilt Genet Inst, Nashville, TN USA 14.Univ Penn, Dept Surg, Perelman Sch Med, Philadelphia, PA 19104 USA 15.VA Eastern Colorado Hlth Care Syst, Med Serv, Aurora, CO USA 16.Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA 17.RIKEN Ctr Integrat Med Sci, Lab Cardiovasc Genom & Informat, Yokohama, Kanagawa, Japan 18.VA Boston Healthcare Syst, Boston, MA USA 19.Booz Allen Hamilton, Mclean, VA USA 20.Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA 21.Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA 22.Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA 23.Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA 24.Univ Florida, Sch Med, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA 25.Stanford Univ, Sch Med, Stanford, CA 94305 USA 26.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA 27.Rocky Mt Reg VA Med Ctr, Dept Med, Aurora, CO USA 28.VHA Off Qual & Patient Safety, CART Program, Washington, DC USA 29.JC HealthCare Washington Univ Sch Med, Healthcare Innovat Lab, St Louis, MO USA 30.Washington Univ, Sch Med, Div Cardiol, St Louis, MO USA 31.Univ Colorado, Div Cardiol, Sch Med, Aurora, CO USA 32.Vanderbilt Univ Sch Med, Dept Biomed Informat, Div Genet Med, Nashville, TN USA 33.Harvard Med Sch, Brigham Womens Hosp, Dept Med, Boston, MA 02115 USA 34.Peking Univ, Dept Global Hlth, Sch Publ Hlth, Beijing, Peoples R China 35.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China 36.Rutgers State Univ, Dept Stat, Piscataway, NJ USA 37.Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA 38.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA 39.Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA 40.Univ Paris, EA 7537 BioSTM, Paris, France 41.Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA 42.Univ Hawaii, Univ Hawaii Canc Ctr, Canc Epidemiol Program, Honolulu, HI USA 43.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA 44.NIA, Mol Genet Sect, Lab Neurogenet, Bethesda, MD 20892 USA 45.Data Tecn Intl LLC, Glen Echo, MD USA 46.NIA, Hlth Dispar Res Sect, NIH, Baltimore, MD 21224 USA 47.Dept Med, Div Biomed Informat & Personalized Med, Aurora, CO USA 48.Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Aurora, CO USA 49.Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Anschutz Med Campus, Aurora, CO USA 50.Vanderbilt Univ Sch Med, Dept Med, Div Epidemiol, Nashville, TN USA 51.Vanderbilt Univ Sch Med, Dept Obstet & Gynecol, Div Quantitat Sci, Nashville, TN USA 52.Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA 53.Univ Washington, Dept Med, Div Nephrol, Seattle, WA USA 54.Univ Washington, Sch Med, Dept Med, Med Genet, Seattle, WA 98195 USA 55.Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA USA 56.Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA 57.Marshfield Clin Res Inst, Ctr Precis Med Res, Marshfield, WI USA 58.Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol, Cincinnati, OH 45229 USA 59.Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA 60.RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan 61.Univ Tokyo, Dept Computat Biol & Med Sci, Grad Sch Frontier Sci, Tokyo, Japan 62.Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA 63.Univ Penn, Inst Biomed Informat, Perelman Sch Med, Philadelphia, PA 19104 USA 64.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA 65.Regeneron Genet Ctr, Tarrytown, NY USA 66.Harvard Med Sch, Dept Med, Boston, MA 02115 USA 67.Massachusetts Gen Hosp, Dept Med, Cardiol Div, Boston, MA 02114 USA 68.Verve Therapeut, Cambridge, MA USA 69.Durham VA Hlth Care Syst, Cooperat Studies Program Epidemiol Ctr Durham, Durham, NC USA 70.Duke Univ Med Ctr, Dept Biostat & Bioinformat, Durham, NC USA 71.Bedford VA Healthcare Syst, Ctr Healthcare Org & Implementat Res, Bedford, MA USA 72.Univ Massachusetts, Ctr Populat Hlth, Dept Biomed & Nutr Sci, Lowell, MA USA 73.Stanford Univ, Dept Med, Sch Med, Stanford, CA USA 74.Columbia Univ, Dept Med, Div Cardiol, New York, NY USA 75.Phoenix VA Hlth Care Syst, Phoenix, AZ USA 76.Univ Arizona, Coll Med, Phoenix, AZ USA 77.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA 78.Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA 79.Univ Penn, Inst Translat Med & Therapeut, Perelman Sch Med, Philadelphia, PA 19104 USA 80.VA Salt Lake City Hlth Care Syst, Salt Lake City, UT USA 81.Univ Massachusetts, Coll Nursing & Hlth Sci, Boston, MA USA 82.Atlanta VA Med Ctr, Atlanta, GA USA 83.Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA 84.Atlanta VA Hlth Care Syst, Atlanta, GA USA 85.Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA 86.Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA USA 87.Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA |
| 推荐引用方式 GB/T 7714 |
Tcheandjieu, Catherine,Zhu, Xiang,Hilliard, Austin T.,et al. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations[J]. NATURE MEDICINE,2022.
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| APA |
Tcheandjieu, Catherine.,Zhu, Xiang.,Hilliard, Austin T..,Clarke, Shoa L..,Napolioni, Valerio.,...&Assimes, Themistocles L..(2022).Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.NATURE MEDICINE.
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| MLA |
Tcheandjieu, Catherine,et al."Large-scale genome-wide association study of coronary artery disease in genetically diverse populations".NATURE MEDICINE (2022).
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