题名 | Neutrophil membrane camouflaged nanoprobes for NIR-II fluorescence imaging of inflamed, high-risk atherosclerotic plaques in mouse and rabbit models |
作者 | |
通讯作者 | Sheng,Z. H.; Jiang,T. A. |
发表日期 | 2022-12-01
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DOI | |
发表期刊 | |
ISSN | 2468-5194
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EISSN | 2468-5194
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卷号 | 26 |
摘要 | Atherosclerosis is the leading cause of vascular death worldwide, and inflammation plays a crucial role in atherosclerotic plaque progression and rupture. Fluorescent nanoprobes that can detect inflamed, high-risk atherosclerotic plaques and evaluate the therapeutic efficacy at the animal level in vivo are particularly meaningful. Herein, we developed a kind of neutrophil membrane-camouflaged nanoprobe in the second near-infrared spectral region (NIR-II) for the imaging of inflamed, high-risk atherosclerotic plaques in both mouse and rabbit models. Compared with free indocyanine green (ICG), the NIR-II fluorescence intensity of neutrophil biomimetic nanoparticles (Neu-NPs) was increased by 276% and had good stability in serum. Neu-NPs could specifically target inflamed, high-risk atherosclerotic plaques through the interaction of the chemokine receptor LFA-1with ICAM-1, which are highly expressed in inflamed sites. In the ApoE−/− mouse model, the signal-to background (S/B) ratio of the Neu-NP-treated mice was 1.67-fold higher than that of NP-treated mice. Even in large animals, such as the New Zealand white rabbit atherosclerosis model, Neu-NPs exhibited excellent targeting to high-risk atherosclerotic plaques. Moreover, the Neu-NPs could be used to reflect the reduction in plaque inflammation after the treatment and could thus be used for therapeutic evaluation and drug screening. Therefore, this highly biocompatible neutrophil membrane-camouflaged nanoprobe may be a new nanocarrier for the treatment of chronic inflammatory diseases such as atherosclerosis. Moreover, the use of NIR-II fluorescence imaging in mice and rabbits with atherosclerosis extends the scope of this emerging imaging technology. |
关键词 | |
相关链接 | [Scopus记录] |
收录类别 | |
语种 | 英语
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学校署名 | 其他
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资助项目 | National Natural Science Foundation of China[81827807];National Natural Science Foundation of China[81901812];National Natural Science Foundation of China[81927807];National Natural Science Foundation of China[81971623];National Natural Science Foundation of China[81971638];National Natural Science Foundation of China[82027803];National Natural Science Foundation of China[82171958];National Natural Science Foundation of China[92159304];Natural Science Foundation of Zhejiang Province[LQ20H180003];
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WOS研究方向 | Chemistry
; Materials Science
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WOS类目 | Chemistry, Multidisciplinary
; Materials Science, Multidisciplinary
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WOS记录号 | WOS:000846908500003
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出版者 | |
EI入藏号 | 20223112525029
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EI主题词 | Biocompatibility
; Biomimetics
; Bionics
; Diagnosis
; Diseases
; Fluorescence imaging
; Infrared devices
; Mammals
; Nanoprobes
; Pathology
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EI分类号 | Biomedical Engineering:461.1
; Medicine and Pharmacology:461.6
; Biotechnology:461.8
; Biology:461.9
; Immunology:461.9.1
; Optical Devices and Systems:741.3
; Imaging Techniques:746
; Nanotechnology:761
; Solid State Physics:933
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Scopus记录号 | 2-s2.0-85135370992
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来源库 | Scopus
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引用统计 |
被引频次[WOS]:12
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成果类型 | 期刊论文 |
条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/375607 |
专题 | 南方科技大学第一附属医院 |
作者单位 | 1.Department of Ultrasound Medicine,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China 2.Department of Ultrasound,Shaoxing People's Hospital (Shaoxing Hospital,Zhejiang University School of Medicine),Shaoxing,China 3.Paul C. Lauterbur Research Center for Biomedical Imaging,Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province,Shenzhen Key Laboratory of Ultrasound Imaging and Therapy,CAS Key Laboratory of Health Informatics,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China 4.Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province,Hangzhou,China 5.Zhejiang University Cancer Center,Zhejiang,China 6.Cancer Center,Faculty of Health Sciences,University of Macau,Taipa,Macau SAR,China 7.Shenzhen Medical Ultrasound Engineering Center,Department of Ultrasound,Shenzhen People's Hospital The Second Clinical Medical College,Jinan University,Shenzhen,China 8.Shenzhen Medical Ultrasound Engineering Center,Department of Ultrasound,Shenzhen People's Hospital The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,China |
推荐引用方式 GB/T 7714 |
Jiang,Z. Z.,Geng,X. R.,Su,L. L.,et al. Neutrophil membrane camouflaged nanoprobes for NIR-II fluorescence imaging of inflamed, high-risk atherosclerotic plaques in mouse and rabbit models[J]. Materials Today Chemistry,2022,26.
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APA |
Jiang,Z. Z.,Geng,X. R.,Su,L. L.,Chen,A. N.,Sheng,Z. H.,&Jiang,T. A..(2022).Neutrophil membrane camouflaged nanoprobes for NIR-II fluorescence imaging of inflamed, high-risk atherosclerotic plaques in mouse and rabbit models.Materials Today Chemistry,26.
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MLA |
Jiang,Z. Z.,et al."Neutrophil membrane camouflaged nanoprobes for NIR-II fluorescence imaging of inflamed, high-risk atherosclerotic plaques in mouse and rabbit models".Materials Today Chemistry 26(2022).
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