Regulation and dysregulation of hair regeneration: aiming for clinical application

Yue，Zhicao1; Yang，Fang2; Zhang，Jianglin2; Li，Ji3; Chuong，Cheng Ming4

2022-12-01

10.1186/s13619-022-00122-x

Cell Regeneration   影响因子和分区

2045-9769

Hair growth and regeneration represents a remarkable example of stem cell function. Recent progress emphasizes the micro- and macro- environment that controls the regeneration process. There is a shift from a stem cell-centered view toward the various layers of regulatory mechanisms that control hair regeneration, which include local growth factors, immune and neuroendocrine signals, and dietary and environmental factors. This is better suited for clinical application in multiple forms of hair disorders: in male pattern hair loss, the stem cells are largely preserved, but androgen signaling diminishes hair growth; in alopecia areata, an immune attack is targeted toward the growing hair follicle without abrogating its regeneration capability. Genome-wide association studies further revealed the genetic bases of these disorders, although the precise pathological mechanisms of the identified loci remain largely unknown. By analyzing the dysregulation of hair regeneration under pathological conditions, we can better address the complex interactions among stem cells, the differentiated progeny, and mesenchymal components, and highlight the critical role of macroenvironment adjustment that is essential for hair growth and regeneration. The poly-genetic origin of these disorders makes the study of hair regeneration an interesting and challenging field.

Alopecia areata Androgenetic alopecia Hair follicle Regeneration Stem cells

英语

其他

National Natural Science Foundation of China[31871468];

2-s2.0-85133130121

Scopus

1.Department of Cell Biology and Medical Genetics,International Cancer Center,and Guangdong Key Laboratory for Genome Instability and Disease Prevention,Shenzhen University,Shenzhen,A7-455 XiLi Campus, Guangdong,518060,China
2.Department of Dermatology,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,China
3.Department of Dermatology,Xiangya Hospital,Central South University,Changsha,China
4.Department of Pathology,University of Southern California,Los Angeles,United States

Yue，Zhicao,Yang，Fang,Zhang，Jianglin,et al. Regulation and dysregulation of hair regeneration: aiming for clinical application[J]. Cell Regeneration,2022,11(1).

Yue，Zhicao,Yang，Fang,Zhang，Jianglin,Li，Ji,&Chuong，Cheng Ming.(2022).Regulation and dysregulation of hair regeneration: aiming for clinical application.Cell Regeneration,11(1).

Yue，Zhicao,et al."Regulation and dysregulation of hair regeneration: aiming for clinical application".Cell Regeneration 11.1(2022).