A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Ramdas，Shweta1; Judd，Jonathan2; Graham，Sarah E.3; Kanoni，Stavroula4; Wang，Yuxuan5; Surakka，Ida3; Wenz，Brandon1; Clarke，Shoa L.6; Chesi，Alessandra7; Wells，Andrew1; Bhatti，Konain Fatima4; Vedantam，Sailaja8; Winkler，Thomas W.9; Locke，Adam E.10; Marouli，Eirini4; Zajac，Greg J.M.11; Wu，Kuan Han H.12; Ntalla，Ioanna13; Hui，Qin14; Klarin，Derek15; Hilliard，Austin T.16; Wang，Zeyuan14; Xue，Chao3; Thorleifsson，Gudmar17; Helgadottir，Anna17; Gudbjartsson，Daniel F.18; Holm，Hilma17; Olafsson，Isleifur19; Hwang，Mi Yeong20; Han，Sohee20; Akiyama，Masato21; Sakaue，Saori22; Terao，Chikashi23; Kanai，Masahiro24; Zhou，Wei25; Brumpton，Ben M.26; Rasheed，Humaira27; Havulinna，Aki S.28; Veturi，Yogasudha29; Pacheco，Jennifer Allen30; Rosenthal，Elisabeth A.31; Lingren，Todd32; Feng，Qi Ping33; Kullo，Iftikhar J.34; Narita，Akira35; Takayama，Jun35; Martin，Hilary C.36; Hunt，Karen A.37; Trivedi，Bhavi37; Haessler，Jeffrey38; Giulianini，Franco39; Bradford，Yuki29; Miller，Jason E.29; Campbell，Archie40; Lin，Kuang41; Millwood，Iona Y.42; Rasheed，Asif43; Hindy，George44; Faul，Jessica D.45; Zhao，Wei46; Weir，David R.45; Turman，Constance47; Huang，Hongyan47; Graff，Mariaelisa48; Choudhury，Ananyo49; Sengupta，Dhriti49; Mahajan，Anubha50; Brown，Michael R.51; Zhang，Weihua52; Yu，Ketian11; Schmidt，Ellen M.11; Pandit，Anita11; Gustafsson，Stefan53; Yin，Xianyong11; Luan，Jian'an54; Zhao，Jing Hua55; Matsuda，Fumihiko56; Jang，Hye Mi20; Yoon，Kyungheon20; Medina-Gomez，Carolina57; Pitsillides，Achilleas5; Hottenga，Jouke Jan58; Wood，Andrew R.59; Ji，Yingji59; Gao，Zishan60; Haworth，Simon61; Mitchell，Ruth E.62; Chai，Jin Fang63; Aadahl，Mette64; Bjerregaard，Anne A.65; Yao，Jie66; Manichaikul，Ani67; Lee，Wen Jane68; Hsiung，Chao Agnes69; Warren，Helen R.70; Ramirez，Julia4; Bork-Jensen，Jette71; Kårhus，Line L.65; Goel，Anuj72; Sabater-Lleal，Maria73; Noordam，Raymond74; Mauro，Pala75; Matteo，Floris76; McDaid，Aaron F.77; Marques-Vidal，Pedro78; Wielscher，Matthias79; Trompet，Stella80; Sattar，Naveed81; Møllehave，Line T.65; Munz，Matthias82; Zeng，Lingyao83; Huang，Jianfeng84; Yang，Bin84; Poveda，Alaitz85; Kurbasic，Azra85; Schönherr，Sebastian86; Forer，Lukas86; Scholz，Markus87; Galesloot，Tessel E.88; Bradfield，Jonathan P.89; Ruotsalainen，Sanni E.90; Daw，E. Warwick91; Zmuda，Joseph M.92; Mitchell，Jonathan S.93; Fuchsberger，Christian93; Christensen，Henry94; Brody，Jennifer A.95; Le，Phuong96; Feitosa，Mary F.91; Wojczynski，Mary K.91; Hemerich，Daiane97; Preuss，Michael97; Mangino，Massimo98; Christofidou，Paraskevi99; Verweij，Niek100; Benjamins，Jan W.100; Engmann，Jorgen101; Noah，Tsao L.102; Verma，Anurag1; Slieker，Roderick C.103; Lo，Ken Sin104; Zilhao，Nuno R.105; Kleber，Marcus E.106; Delgado，Graciela E.107; Huo，Shaofeng108; Ikeda，Daisuke D.109; Iha，Hiroyuki109; Yang，Jian110; Liu，Jun111; Demirkan，Ayşe112; Leonard，Hampton L.113; Marten，Jonathan114; Emmel，Carina115; Schmidt，Börge115; Smyth，Laura J.116; Cañadas-Garre，Marisa117; Wang，Chaolong118; Nakatochi，Masahiro119; Wong，Andrew120; Hutri-Kähönen，Nina121; Sim，Xueling63; Xia，Rui122; Huerta-Chagoya，Alicia123; Fernandez-Lopez，Juan Carlos124; Lyssenko，Valeriya125; Nongmaithem，Suraj S.126; Sankareswaran，Alagu127; Irvin，Marguerite R.120; Oldmeadow，Christopher128; Kim，Han Na129; Ryu，Seungho130; Timmers，Paul R.H.J.131; Arbeeva，Liubov132; Dorajoo，Rajkumar133; Lange，Leslie A.134; Prasad，Gauri135; Lorés-Motta，Laura136; Pauper，Marc136; Long，Jirong137; Li，Xiaohui66; Theusch，Elizabeth138; Takeuchi，Fumihiko139; Spracklen，Cassandra N.140; Loukola，Anu90; Bollepalli，Sailalitha90; Warner，Sophie C.141; Wang，Ya Xing142; Wei，Wen B.143; Nutile，Teresa144; Ruggiero，Daniela145; Sung，Yun Ju146; Chen，Shufeng84; Liu，Fangchao84; Yang，Jingyun147; Kentistou，Katherine A.148; Banas，Bernhard149; Morgan，Anna150; Meidtner，Karina151; Bielak，Lawrence F.46; Smith，Jennifer A.152; Hebbar，Prashantha153; Farmaki，Aliki Eleni154; Hofer，Edith155; Lin，Maoxuan156; Concas，Maria Pina150; Vaccargiu，Simona157; van der Most，Peter J.158; Pitkänen，Niina159; Cade，Brian E.160; van der Laan，Sander W.161; Chitrala，Kumaraswamy Naidu162; Weiss，Stefan163; Bentley，Amy R.164; Doumatey，Ayo P.164; Adeyemo，Adebowale A.164; Lee，Jong Young165; Petersen，Eva R.B.166; Nielsen，Aneta A.167; Choi，Hyeok Sun168; Nethander，Maria169; Freitag-Wolf，Sandra170; Southam，Lorraine171; Rayner，Nigel W.172; Wang，Carol A.173; Lin，Shih Yi174; Wang，Jun Sing175; Couture，Christian176; Lyytikäinen，Leo Pekka177; Nikus，Kjell178; Cuellar-Partida，Gabriel179; Vestergaard，Henrik180; Hidalgo，Bertha181; Giannakopoulou，Olga4; Cai，Qiuyin137; Obura，Morgan O.182; van Setten，Jessica183; He，Karen Y.184; Tang，Hua2; Terzikhan，Natalie185; Shin，Jae Hun168; Jackson，Rebecca D.186; Reiner，Alexander P.187; Martin，Lisa Warsinger188; Chen，Zhengming42; Li，Liming189; Kawaguchi，Takahisa56; Thiery，Joachim190; Bis，Joshua C.95; Launer，Lenore J.191; Li，Huaixing108; Nalls，Mike A.113; Raitakari，Olli T.192; Ichihara，Sahoko193; Wild，Sarah H.194; Nelson，Christopher P.141; Campbell，Harry148; Jäger，Susanne151; Nabika，Toru195; Al-Mulla，Fahd153; Niinikoski，Harri196; Braund，Peter S.141; Kolcic，Ivana197; Kovacs，Peter198; Giardoglou，Tota199; Katsuya，Tomohiro200; de Kleijn，Dominique201; de Borst，Gert J.201; Kim，Eung Kweon202; Adams，Hieab H.H.203; Ikram，M. Arfan185; Zhu，Xiaofeng184; Asselbergs，Folkert W.183; Kraaijeveld，Adriaan O.183; Beulens，Joline W.J.204; Shu，Xiao Ou137; Rallidis，Loukianos S.205; Pedersen，Oluf71; Hansen，Torben71; Mitchell，Paul206; Hewitt，Alex W.207; Kähönen，Mika208; Pérusse，Louis209; Bouchard，Claude210; Tönjes，Anke198; Ida Chen，Yii Der66; Pennell，Craig E.173; Mori，Trevor A.211; Lieb，Wolfgang212; Franke，Andre213; Ohlsson，Claes214; Mellström，Dan215; Cho，Yoon Shin168; Lee，Hyejin216; Yuan，Jian Min217; Koh，Woon Puay218; Rhee，Sang Youl219; Woo，Jeong Taek219; Heid，Iris M.9; Stark，Klaus J.9; Zimmermann，Martina E.9; Völzke，Henry220; Homuth，Georg163; Evans，Michele K.191; Zonderman，Alan B.191; Polasek，Ozren221; Pasterkamp，Gerard161; Hoefer，Imo E.161; Redline，Susan160; Pahkala，Katja222; Oldehinkel，Albertine J.223; Snieder，Harold158; Biino，Ginevra224; Schmidt，Reinhold225; Schmidt，Helena226; Bandinelli，Stefania227; Dedoussis，George199; Thanaraj，Thangavel Alphonse153; Peyser，Patricia A.46; Kato，Norihiro139; Schulze，Matthias B.228; Girotto，Giorgia229; Böger，Carsten A.230; Jung，Bettina230; Joshi，Peter K.148; Bennett，David A.147; De Jager，Philip L.231; Lu，Xiangfeng84; Mamakou，Vasiliki232; Brown，Morris233; Caulfield，Mark J.70; Munroe，Patricia B.70; Guo，Xiuqing66; Ciullo，Marina145; Jonas，Jost B.234; Samani，Nilesh J.141; Kaprio，Jaakko90; Pajukanta，Päivi235; Tusié-Luna，Teresa236; Aguilar-Salinas，Carlos A.237; Adair，Linda S.238; Bechayda，Sonny Augustin239; de Silva，H. Janaka240; Wickremasinghe，Ananda R.241; Krauss，Ronald M.242; Wu，Jer Yuarn243; Zheng，Wei137; den Hollander，Anneke I.136; Bharadwaj，Dwaipayan244; Correa，Adolfo245; Wilson，James G.246; Lind，Lars247; Heng，Chew Kiat248; Nelson，Amanda E.249; Golightly，Yvonne M.250; Wilson，James F.131; Penninx，Brenda251; Kim，Hyung Lae252; Attia，John253; Scott，Rodney J.253; Rao，D. C.146; Arnett，Donna K.254; Walker，Mark255; Scott，Laura J.11; Koistinen，Heikki A.256; Chandak，Giriraj R.257; Mercader，Josep M.258; Villalpando，Clicerio Gonzalez259; Orozco，Lorena260; Fornage，Myriam261; Tai，E. Shyong262; van Dam，Rob M.262; Lehtimäki，Terho177; Chaturvedi，Nish263; Yokota，Mitsuhiro264; Liu，Jianjun265; Reilly，Dermot F.266; McKnight，Amy Jayne116; Kee，Frank116; Jöckel，Karl Heinz115; McCarthy，Mark I.267; Palmer，Colin N.A.268; Vitart，Veronique114; Hayward，Caroline114; Simonsick，Eleanor269; van Duijn，Cornelia M.111; Jin，Zi Bing270; Lu，Fan271; Hishigaki，Haretsugu109; Lin，Xu108; März，Winfried272; Gudnason，Vilmundur273; Tardif，Jean Claude104; Lettre，Guillaume104; T Hart，Leen M.274; Elders，Petra J.M.275; Rader，Daniel J.276; Damrauer，Scott M.277; Kumari，Meena278; Kivimaki，Mika279; van der Harst，Pim100; Spector，Tim D.99; Loos，Ruth J.F.280; Province，Michael A.91; Parra，Esteban J.281; Cruz，Miguel282; Psaty，Bruce M.283; Brandslund，Ivan284; Pramstaller，Peter P.93; Rotimi，Charles N.285; Christensen，Kaare286; Ripatti，Samuli287; Widén，Elisabeth90; Hakonarson，Hakon288; Grant，Struan F.A.289; Kiemeney，Lambertus88; de Graaf，Jacqueline88; Loeffler，Markus87; Kronenberg，Florian86; Gu，Dongfeng290; Erdmann，Jeanette82; Schunkert，Heribert83; Franks，Paul W.85; Linneberg，Allan64; Jukema，J. Wouter291; Khera，Amit V.292; Männikkö，Minna293; Jarvelin，Marjo Riitta294; Kutalik，Zoltan77; Francesco，Cucca295; Mook-Kanamori，Dennis O.296; Willems van Dijk，Ko297; Watkins，Hugh298; Strachan，David P.299; Grarup，Niels71; Sever，Peter300; Poulter，Neil301; Huey-Herng Sheu，Wayne302; Rotter，Jerome I.66; Dantoft，Thomas M.65; Karpe，Fredrik303; Neville，Matt J.303; Timpson，Nicholas J.62; Cheng，Ching Yu304; Wong，Tien Yin304; Khor，Chiea Chuen265; Li，Hengtong305; Sabanayagam，Charumathi304; Peters，Annette306; Gieger，Christian307; Hattersley，Andrew T.308; Pedersen，Nancy L.309; Magnusson，Patrik K.E.309; Boomsma，Dorret I.310; de Geus，Eco J.C.310; Cupples，L. Adrienne311; van Meurs，Joyce B.J.312; Ikram，Arfan185; Ghanbari，Mohsen313; Gordon-Larsen，Penny238; Huang，Wei314; Kim，Young Jin20; Tabara，Yasuharu56; Wareham，Nicholas J.54; Langenberg，Claudia54; Zeggini，Eleftheria315; Tuomilehto，Jaakko316; Kuusisto，Johanna317; Laakso，Markku317; Ingelsson，Erik318; Abecasis，Goncalo319; Chambers，John C.320; Kooner，Jaspal S.321; de Vries，Paul S.51; Morrison，Alanna C.51; Hazelhurst，Scott322; Ramsay，Michèle49; North，Kari E.48; Daviglus，Martha323; Kraft，Peter324; Martin，Nicholas G.325; Whitfield，John B.325; Abbas，Shahid43; Saleheen，Danish326; Walters，Robin G.327; Holmes，Michael V.328; Black，Corri329; Smith，Blair H.268; Baras，Aris330; Justice，Anne E.331; Buring，Julie E.332; Ridker，Paul M.332; Chasman，Daniel I.332; Kooperberg，Charles38; Tamiya，Gen35; Yamamoto，Masayuki35; van Heel，David A.37; Trembath，Richard C.333; Wei，Wei Qi334; Jarvik，Gail P.335; Namjou，Bahram336; Hayes，M. Geoffrey337; Ritchie，Marylyn D.29; Jousilahti，Pekka338; Salomaa，Veikko338; Hveem，Kristian339; Åsvold，Bjørn Olav340; Kubo，Michiaki341; Kamatani，Yoichiro342; Okada，Yukinori343; Murakami，Yoshinori344; Kim，Bong Jo345; Thorsteinsdottir，Unnur346; Stefansson，Kari346; Zhang，Jifeng3; Chen，Y. Eugene3; Ho，Yuk Lam347; Lynch，Julie A.348; Tsao，Philip S.349; Chang，Kyong Mi350; Cho，Kelly351; O'Donnell，Christopher J.351; Gaziano，John M.351; Wilson，Peter352; Mohlke，Karen L.353; Frayling，Timothy M.59; Hirschhorn，Joel N.354; Kathiresan，Sekar355; Boehnke，Michael11; Struan Grant，356; Natarajan，Pradeep357; Sun，Yan V.14; Morris，Andrew P.358; Deloukas，Panos359; Peloso，Gina5; Assimes，Themistocles L.349; Willer，Cristen J.360; Zhu，Xiang361; Brown，Christopher D.362

2022-08-04

10.1016/j.ajhg.2022.06.012

AMERICAN JOURNAL OF HUMAN GENETICS   影响因子和分区

0002-9297

1537-6605

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.

SCI

英语

其他

Genetics & Heredity

Genetics & Heredity

WOS:000850681500003

CELL PRESS

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Department of Genetics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,United States
2.Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
3.Department of Internal Medicine,Division of Cardiology,University of Michigan,Ann Arbor,MI 48109,United States
4.William Harvey Research Institute,Queen Mary University of London,John Vane Science Centre,London,Barts and the London School of Medicine and DentistryCharterhouse Square,EC1M 6BQ,United Kingdom
5.Department of Biostatistics,Boston University School of Public Health,Boston,801 Massachusetts Avenue,MA 02118,United States
6.VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
7.Department of Pathology and Laboratory Medicine,University of Pennsylvania,Philadelphia,United States
8.Endocrinology, Boston Childrens Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA
9.Department of Genetic Epidemiology,University of Regensburg,Regensburg,Germany
10.McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO 63108, USA
11.Department of Biostatistics,Center for Statistical Genetics,University of Michigan,Ann Arbor,United States
12.Department of Computational Medicine and Bioinformatics,University of Michigan,Ann Arbor,United States
13.Clinical Pharmacology,William Harvey Research Institute,Queen Mary University of London,London,Barts and The London School of Medicine and Dentistry,EC1M 6BQ,United Kingdom
14.Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA; Atlanta VA Health Care System, Decatur, GA, USA
15.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Malcolm Randall VA Medical Center, Gainesville, FL, USA; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA
16.VA Palo Alto Health Care Systems,Palo Alto,United States
17.deCODE genetics/Amgen,Inc.,Reykjavik,Sturlugata 8,102,Iceland
18.deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland; School of Engineering and Natural Sciences, University of Iceland, Sæmundargötu 2, Reykjavik 102, Iceland
19.Department of Clinical Biochemistry,Landspitali - National University Hospital of Iceland,Reykjavik,Hringbraut,101,Iceland
20.Division of Genome Science,Department of Precision Medicine,National Institute of Health,South Korea
21.Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
22.Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, The University of Tokyo, Tokyo, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
23.Laboratory for Statistical and Translational Genetics,Yokohama,RIKEN Center for Integrative Medical Sciences,Japan
24.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
25.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA
26.K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
27.K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway
28.Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
29.Department of Genetics,Institute for Biomedical Informatics,University of Pennsylvania,Perelman School of Medicine,Philadelphia,PA 19104,United States
30.Center for Genetic Medicine,Northwestern University,Feinberg School of Medicine,Chicago,IL 60611,United States
31.Department of Medicine (Medical Genetics),University of Washington,Seattle,United States
32.Division of Biomedical Informatics,Cincinnati Children's Hospital Medical Center,Cincinnati,United States
33.Division of Clinical Pharmacology,Department of Medicine,Vanderbilt University Medical Center,Nashville,United States
34.Department of Cardiovascular Medicine and the Gonda Vascular Center,Mayo Clinic,Rochester,United States
35.Tohoku Medical Megabank Organization,Tohoku University,Sendai,980-8573,Japan
36.Wellcome Trust Sanger Institute,United Kingdom
37.Blizard Institute,Queen Mary University of London,London,Barts and the London School of Medicine and Dentistry,United Kingdom
38.Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98109, USA
39.Division of Preventive Medicine,Brigham and Women's Hospital,Boston,MA 02215,United States
40.Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, EH4 2XU Edinburgh, UK; Usher Institute, The University of Edinburgh, Nine, Edinburgh Bioquarter, 9 Little France Road, EH16 4UX Edinburgh, UK
41.Clinical Trial Service Unit and Epidemiological Studies Unit,Nuffield Department of Population Health,University of Oxford,Oxford,OX3 7LF,United Kingdom
42.Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK
43.Center for Non-Communicable Diseases,Pakistan & Faisalabad Institute of Cardiology,Karachi,Pakistan
44.Department of Population Medicine,Qatar University College of Medicine,QU Health,Doha,Qatar
45.Survey Research Center,Institute for Social Research,University of Michigan,Ann Arbor,United States
46.Department of Epidemiology,School of Public Health,University of Michigan,Ann Arbor,MI 48109,United States
47.Program in Genetic Epidemiology and Statistical Genetics,Department of Epidemiology,Harvard T.H. Chan School of Public Health,Boston,677 Huntington Avenue,MA 02115,United States
48.Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina at Chapel Hill,Chapel Hill,United States
49.Sydney Brenner Institute for Molecular Bioscience,Faculty of Health Sciences,University of the Witwatersrand,Johannesburg,South Africa
50.Wellcome Centre for Human Genetics,University of Oxford,Oxford,OX3 7BN,United Kingdom
51.Human Genetics Center,Department of Epidemiology,Human Genetics,Environmental Sciences,School of Public Health,University of Texas Health Science Center at Houston,Houston,TX 77030,United States
52.Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK
53.Department of Medical Sciences,Molecular Epidemiology and Science for Life Laboratory,Uppsala University,Sweden
54.MRC Epidemiology Unit,University of Cambridge School of Clinical Medicine,Cambridge,CB2 0QQ,United Kingdom
55.Cardiovascular Epidemiology Unit,Department of Public Health and Primary Care,University of Cambridge,Strangeways Research Laboratory,Cambridge,Wort's Causeway,CB1 8RN,United Kingdom
56.Center for Genomic Medicine,Kyoto University Graduate School of Medicine,Japan
57.Department of Internal Medicine,Erasmus MC,University Medical Center Rotterdam,Rotterdam,Netherlands
58.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands
59.Genetics of Complex Traits,University of Exeter Medical School,University of Exeter,Exeter,EX2 5DW,United Kingdom
60.Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
61.MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Bristol Dental School, University of Bristol, Lower Maudlin Street, BS1 2LY Bristol, UK
62.MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, BS8 2BN Bristol, UK
63.Saw Swee Hock School of Public Health,National University of Singapore and National University Health System,117549,Singapore
64.Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
65.Center for Clinical Research and Prevention,Bispebjerg and Frederiksberg Hospital,Copenhagen,Denmark
66.The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA 90502, USA
67.Center for Public Health Genomics,University of Virginia,Charlottesville,United States
68.Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; No. 1650, Sec. 4, Taiwan Boulevard, Taichung City 40705, Taiwan
69.Institute of Population Health Sciences,National Health Research Institutes,Miaoli County 350,ROC,35 Keyan Road ,Zhunan Town,Taiwan
70.William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK
71.Novo Nordisk Foundation Center for Basic Metabolic Research,Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark
72.Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK
73.Unit of Genomics of Complex Diseases. Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
74.Department of Internal Medicine,Section of Gerontology and Geriatrics,Leiden University Medical Center,Leiden,Netherlands
75.Istituto di Ricerca Genetica e Biomedica,Rome,Consiglio Nazionale delle Ricerche,Italy
76.Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Rome, Italy; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sardinia, Italy
77.University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
78.Department of Medicine,Internal Medicine,Lausanne University Hospital and University of Lausanne,Lausanne,Rue du Bugnon 46,1011,Switzerland
79.Department of Epidemiology and Biostatistics,MRC-PHE Centre for Environment and Health,School of Public Health,Imperial College London,London,W2 1PG,United Kingdom
80.Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
81.BHF Glasgow Cardiovascular Research Centre,Faculty of Medicine,Glasgow,United Kingdom
82.University of Lübeck,DZHK (German Research Centre for Cardiovascular Research),University Heart Center Lübeck,Lübeck and Charité - University Medicine Berlin,corporate member of Freie Universität Berlin,Berlin Institute of Health,Institute for Dental and Craniofacial Sciences,Department of Periodontology and Synoptic Dentistry,partner site Hamburg/Lübeck/KielHumboldt-Universität zu Berlin,Germany
83.Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany
84.Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,100037,China
85.Lund University Diabetes Centre,Lunds University,Malmö,Sweden
86.Institute of Genetic Epidemiology,Department of Genetics and Pharmacology,Medical University of Innsbruck,Austria and German Chronic Kidney Disease Study,Innsbruck,Austria
87.Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany
88.Radboud university medical center,Radboud Institute for Health Sciences,Nijmegen,Netherlands
89.Quantinuum Research LLC,PA 19087,Wayne,United States
90.Institute for Molecular Medicine Finland (FIMM),University of Helsinki,Helsinki,Tukholmankatu 8,00014,Finland
91.Division of Statistical Genomics,Department of Genetics,Washington University School of Medicine,St. Louis,United States
92.Department of Epidemiology,Graduate School of Public Health,University of Pittsburgh,Pittsburgh,PA 15232,United States
93.Institute for Biomedicine,Eurac Research,Affiliated Institute of the University of Lübeck,Bolzano,Via Galvani 31,39100,Italy
94.Department of Clinical Biochemistry,Lillebaelt Hospital,Vejle,Denmark
95.Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
96.Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada; Department of Computer Science, University of Toronto, Toronto, ON M5S 2E4, Canada
97.The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
98.Department of Twin Research and Genetic Epidemiology, King's College London, SE1 7EH London, UK; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, SE1 9RT London, UK
99.Department of Twin Research and Genetic Epidemiology,King's College London,London,SE1 7EH,United Kingdom
100.Department of Cardiology,University of Groningen,University Medical Center Groningen,9700RB,Netherlands
101.Institute of Cardiovascular Sciences, University College London, Gower Street, WC1E 6BT London, UK; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, WC1E 6BT London, UK
102.Department of Surgery,University of Pennsylvania,Philadelphia,PA 19104,United States
103.Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Leiden University Medical Center, Department of Cell and Chemical Biology, Leiden 2333ZA, the Netherlands
104.Montreal Heart Institute,Montreal,Université de Montréal ,5000 Belanger street,Canada
105.Icelandic Heart Association,Kopavogur,201,Iceland
106.Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; SYNLAB MVZ Humangenetik Mannheim GmbH, 68163 Mannheim, Germany
107.Vth Department of Medicine,Medical Faculty Mannheim,Heidelberg University,Germany
108.Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,China
109.Biomedical Technology Research Center,Tokushima Research Institute,Otsuka Pharmaceutical Co.,Ltd.,Japan
110.School of Life Sciences, Westlake University, Hangzhou, Zhejiang 310024, China; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
111.Nuffield Department of Population Health, University of Oxford, Oxford, UK; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
112.Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Section of Statistical Multi-omics, Department of Clinical and Experimental research, University of Surrey, Guildford, Surrey, UK
113.Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA; Data Tecnica International, Glen Echo, MD, USA
114.MRC Human Genetics Unit,Institute of Genetics and Cancer,University of Edinburgh,Western General Hospital,Edinburgh,Crewe Road,EH4 2XU,United Kingdom
115.Institute for Medical Informatics,Biometrie and Epidemiology,University of Duisburg-Essen,Essen,Germany
116.Centre for Public Health,Queen's University of Belfast,Belfast,United Kingdom
117.Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain; Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain
118.Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
119.Public Health Informatics Unit,Department of Integrated Health Sciences,Nagoya University Graduate School of Medicine,Nagoya,461-8673,Japan
120.University of Alabama at Birmingham,Epidemiology,School of Public Health,Birmingham,United States
121.Tampere Centre for Skills Training and Simulation,Faculty of Medicine and Health Technology,Tampere University,Tampere,Finland
122.Brown Foundation Institute of Molecular Medicine,McGovern Medical School,University of Texas Health Science Center at Houston,United States
123.CONACYT,Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Ciudad de Mexico,Mexico
124.Departamento de Genómica Computacional,Instituto Nacional de Medicina Genómica,Ciudad de Mexico,Mexico
125.Lund University Diabetes Centre, Lunds University, Malmö, Sweden; Center for diabetes research, University of Bergen, Bergen, Norway
126.Genomic Research on Complex diseases (GRC Group),CSIR-Centre for Cellular and Molecular Biology,Hyderabad,India
127.Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India
128.Hunter Medical Research Institute,NSW,Newcastle,Australia
129.Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul 06355, Korea
130.Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 04514, Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea
131.MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
132.Thurston Arthritis Research Center,University of North Carolina,Chapel Hill,United States
133.Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; Health Services and Systems Research, Duke-NUS Medical School, 169857, Singapore
134.Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO 80045, USA
135.Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India
136.Departments of Ophthalmology and Human Genetics,Radboud University Nijmegen Medical Center,Nijmegen,Philips van Leydenlaan 15,6525 EX,Netherlands
137.Vanderbilt Epidemiology Center,Division of Epidemiology,Vanderbilt University Medical Center,Nashville,United States
138.Department of Pediatrics, University of California San Francisco, Oakland, CA 94609, USA
139.National Center for Global Health and Medicine,1628655,Japan
140.Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA 01003, USA
141.Department of Cardiovascular Sciences, University of Leicester, Leicester, UK; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK
142.Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology and Visual Sciences Key Laboratory,17 Hougou Lane,100005,China
143.Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,1 Dong Jiao Min Xiang ,Dong Cheng District,100730,China
144.Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR,Naples,Italy
145.Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy; IRCCS Neuromed, Pozzilli, Isernia, Italy
146.Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA
147.Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
148.Centre for Global Health Research,Usher Institute,University of Edinburgh,Edinburgh,Teviot Place,EH8 9AG,United Kingdom
149.Department of Nephrology,University Hospital Regensburg,Regensburg,Germany
150.Institute for Maternal and Child Health-IRCCS,Burlo Garofolo,Trieste,34127,Italy
151.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany
152.Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
153.Department of Genetics and Bioinformatics,Dasman Diabetes Institute,Kuwait City,Kuwait
154.Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Eleftheriou Venizelou, Athens, Greece; Department of Population Science and Experimental Medicine, University College London, London, UK
155.Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
156.Massachusetts General Hospital Cancer Center,Charlestown,United States
157.Institute of Genetic and Biomedical Research,National Research Council of Italy,UOS of Sassari,Sassari,Italy
158.Department of Epidemiology,University of Groningen,University Medical Center Groningen,Netherlands
159.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
160.Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA
161.Central Diagnostics Laboratory,Division Laboratories,Pharmacy,Biomedical genetics,University Medical Center Utrecht,Utrecht University,Netherlands
162.Laboratory of Epidemiology and Population Science National Institute on Aging Intramural Research Program, NIH 251 Bayview Blvd, NIH Biomedical Research Center, Baltimore, MD 21224, USA; Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA
163.Interfaculty Institute for Genetics and Functional Genomics,Department of Functional Genomics,University of Greifswald and University Medicine Greifswald,Greifswald,Germany
164.Center for Research on Genomics and Global Health,National Human Genome Research Institute,National Institutes of Health,Room 4047,Bethesda,12 South Drive,MD 20892,United States
165.Oneomics. co. ltd. 2F,Soonchunhyang Mirai Medical Center 173,South Korea
166.Department of Clinical Biochemistry and Immunology,Hospital of Southern Jutland,Aabenraa,Kresten Philipsens Vej 15,6200,Denmark
167.Department of Clinical Biochemistry,Lillebaelt Hospital,Kolding,Denmark
168.Department of Biomedical Science,Hallym University,Chuncheon,South Korea
169.Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
170.Institute of Medical Informatics and Statistics,Kiel University,Kiel,Germany
171.Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
172.Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK
173.School of Medicine and Public Health,Faculty of Medicine and Health,University of Newcastle,Newcastle,NSW 2308,Australia
174.Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan
175.Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
176.Department of Kinesiology,Université Laval,Quebec City,Canada
177.Department of Clinical Chemistry, Fimlab Laboratories, 33520 Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
178.Department of Cardiology, Heart Center, Tampere University Hospital, 33521 Tampere, Finland; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
179.University of Queensland Diamantina Institute,Translational Research Institute,Brisbane,Kent St ,Woolloongabba,QLD 4102,Australia
180.Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Bornholms Hospital, Rønne, Denmark
181.School of Public Health,University of Alabama at Birmingham,Birmingham,United States
182.Department of Epidemiology and Data Science,Amsterdam Public Health Research Institute,Amsterdam,1081HV,Netherlands
183.Cardiology,Division Heart & Lungs,University Medical Center Utrecht,Utrecht University,Netherlands
184.Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
185.Department of Epidemiology,Erasmus MC,University Medical Center,Rotterdam,Netherlands
186.Ohio State University, Division of Endricinology, Columbus, OH 43210, USA
187.University of Washington, Department of Epidemiology, Seattle, WA 98195, USA
188.George Washington University,School of Medicine and Health Sciences,United States
189.Department of Epidemiology,School of Public Health,Peking University Health Science Center,China
190.LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103 Leipzig, Germany; Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103 Leipzig, Germany
191.Laboratory of Epidemiology and Population Sciences,National Institute on Aging Intramural Research Program,NIH,Baltimore,United States
192.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
193.Department of Environmental and Preventive Medicine,Jichi Medical University School of Medicine,Shimotsuke 329-0498,Japan
194.Centre for Population Health Sciences,Usher Institute,University of Edinburgh,Edinburgh,Teviot Place,EH8 9AG,United Kingdom
195.Department of Functional Pathology,Shimane University School of Medicine,Izumo,6938501,Japan
196.Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland; Department of Physiology, University of Turku, Turku, Finland
197.Faculty of Medicine,University of Split,Split,Šoltanska 2,21000,Croatia
198.Medical Department III - Endocrinology,Nephrology,University of Leipzig Medical Center,Leipzig,RheumatologyLiebigstr. 21,04103,Germany
199.Department of Nutrition and Dietetics,School of Health Science and Education,Harokopio University of Athens,Athens,Greece
200.Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan
201.Department of Vascular Surgery,Division of Surgical Specialties,University Medical Center Utrecht,Utrecht University,Netherlands
202.Corneal Dystrophy Research Institute,Department of Ophthalmology,Yonsei University College of Medicine,03722,South Korea
203.Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands
204.Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Julius Centre for Health Sciences and Primary Care, University Medical Ceslrntre Utrecht, Utrecht 3584CG, the Netherlands
205.Second Department of Cardiology,Medical School,National and Kapodistrian University of Athens,Attikon University Hospital,Athens,Greece
206.Center for Vision Research,Department of Ophthalmology and The Westmead Institute,University of Sydney,Sydney,Hawkesbury Rd,Australia
207.Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Liverpool St, Hobart, TAS 7000, Australia; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC 3002, Australia
208.Department of Clinical Physiology, Tampere University Hospital, 33521 Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland
209.Department of Kinesiology, Université Laval, Quebec City, QC, Canada; Centre Nutrition, santé et société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Quebec, QC, Canada
210.Pennington Biomedical Research Center,Baton Rouge,United States
211.Discipline of Internal Medicine,Medical School,University of Western Australia,Perth,Australia
212.Institute of Epidemiology,Kiel University,Kiel,Germany
213.Institute of Clinical Molecular Biology,Kiel University,Kiel,Germany
214.Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden
215.Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
216.Department of Internal Medicine,EwhaWomans University School of Medicine,South Korea
217.Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15232, USA; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA
218.Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A∗STAR), Singapore 117609, Singapore
219.Department of Endocrinology and Metabolism,Kyung Hee University School of Medicine,02447,South Korea
220.Institute for Community Medicine,Greifswald,University Medicine Greifswald,Germany
221.Faculty of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia; Algebra University College, Ilica 242, Zagreb, Croatia
222.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland
223.Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE),University of Groningen,University Medical Center Groningen,Netherlands
224.Institute of Molecular Genetics,National Research Council of Italy,Pavia,Italy
225.Clinical Division of Neurogeriatrics,Department of Neurology,Medical University of Graz,Graz,Austria
226.Gottfried Schatz Research Center for Cell Signaling,Metabolism and Aging,Medical University of Graz,Graz,Austria
227.Local Health Unit Toscana Centro,Firenze,Italy
228.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
229.Institute for Maternal and Child Health-IRCCS, Burlo Garofolo, 34127 Trieste, Italy; Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy
230.Department of Nephrology, University Hospital Regensburg, Regensburg, Germany; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany; KfH Kidney Center Traunstein, Traunstein, Germany
231.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA
232.Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27 Athens, Greece; Dromokaiteio Psychiatric Hospital, 124 61 Athens, Greece
233.Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, EC1M 6BQ London, UK
234.Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 17 Hougou Lane, Chong Wen Men, Beijing 100005, China; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, Mannheim 68167, Germany; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany
235.Department of Human Genetics,David Geffen School of Medicine at UCLA,University of California,Los Angeles,United States
236.Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico; Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
237.Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico; Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
238.Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA
239.USC-Office of Population Studies Foundation, University of San Carlos, Cebu City 6000, Philippines; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City 6000, Philippines
240.Department of Medicine,Faculty of Medicine,University of Kelaniya,Ragama,11010,Sri Lanka
241.Department of Public Health,Faculty of Medicine,University of Kelaniya,Ragama,11010,Sri Lanka
242.Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
243.Institute of Biomedical Sciences,Academia Sinica,Taiwan
244.Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, India
245.Department of Medicine,University of Mississippi Medical Center,MS 39216,Jackson,United States
246.Department of Physiology and Biophysics,University of Mississippi Medical Center,MS 39216,Jackson,United States
247.Department of Medical Sciences,Uppsala University,Sweden
248.Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore
249.Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
250.Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA
251.Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands
252.Department of Biochemistry,College of Medicine,Ewha Womans University,South Korea
253.Hunter Medical Research Institute, Newcastle, NSW, Australia; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW 2308, Australia
254.University of Kentucky,College of Public Health,Lexington,United States
255.Institute of Cellular Medicine (Diabetes),Medical School,Newcastle University,Newcastle upon Tyne,Framlington Place,NE2 4HH,United Kingdom
256.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Department of Medicine, Helsinki University Hospital, P.O.Box 340, Haartmaninkatu 4, 00029 Helsinki, Finland; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290 Helsinki, Finland
257.Genomic Research on Complex diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Human Resource Development Centre, New Delhi, India; JSS Academy of Higher Education and Research, Mysuru, India
258.Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA 02115, USA
259.Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes,Cuernavaca,Mexico
260.Instituto Nacional de Medicina Genómica,Mexico
261.Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston TX 77030, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
262.Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117549, Singapore; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore
263.MRC Unit for Lifelong Health and Ageing at UCL,London,1-19 Torrington Place,WC1E 7HB,United Kingdom
264.Kurume University School of Medicine,Kurume,830-0011,Japan
265.Genome Institute of Singapore,Agency for Science,Technology and Research,Singapore
266.Genetics,Merck Sharp & Dohme Corp,Kenilworth,United States
267.Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK
268.Division of Population Health and Genomics,University of Dundee,Ninwells Hospital and Medical School,Dundee,DD1 9SY,United Kingdom
269.Intramural Research Program,National Institute on Aging,3001 S. Hanover St.,Baltimore,United States
270.Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Dong Cheng District, Beijing 100730, China; The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
271.Eye Hospital,School of Ophthalmology & Optometry,Wenzhou Medical University,Wenzhou,325027,China
272.Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
273.Icelandic Heart Association, 201 Kopavogur, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
274.Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam 1081HV, the Netherlands; Leiden University Medical Center, Department of Cell and Chemical Biology, Leiden 2333ZA, the Netherlands; Leiden University Medical Center, Department of Biomedical Data Sciences, Section Molecular Epidemiology, 2333ZA Leiden, the Netherlands
275.Department of General Practice and Elderly Care,Amsterdam Public Health Research Institute,Amsterdam,1081HV,Netherlands
276.Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
277.Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA
278.Institute of Social and Economic Research,University of Essex,Wivenhoe Park CO4 3SQ,United Kingdom
279.Department of Epidemiology and Public Health,University College London,London,1-19 Torrington Place,WC1E 6BT,United Kingdom
280.Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA
281.Department of Anthropology,University of Toronto at Mississauga,Mississauga,Canada
282.Unidad de Investigacion Medica en Bioquimica,Hospital de Especialidades,Instituto Mexicano del Seguro Social,Centro Medico Nacional Siglo XXI,Mexico
283.Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; University of Washington, Department of Epidemiology, Seattle, WA 98195, USA; Department of Health Services, University of Washington, Seattle, WA, USA
284.Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark
285.16Center for Research on Genomics and Global Health,National Human Genome Research Institute,National Institutes of Health,Room 4047,Bethesda,12 South Drive,MD 20892,United States
286.Danish Aging Research Center,University of Southern Denmark,Odense C,Denmark
287.Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014 Helsinki, Finland; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Broad Institute of MIT and Harvard, Cambridge, MA, USA
288.Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
289.Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
290.Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; School of Medicine, Southern University of Science and Technology, Shenzhen, China
291.Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands; Netherlands Heart Institute, Utrecht, the Netherlands
292.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Northern Finland Birth Cohorts, Infrastructure for population studies, Faculty of Medicine, University of Oulu, Oulu, Finland
293.Northern Finland Birth Cohorts,Infrastructure for population studies,Faculty of Medicine,University of Oulu,Oulu,Finland
294.Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland; Biocenter of Oulu, University of Oulu, Oulu, Finland
295.Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy; University of Sassari, Sassari, Italy
296.Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
297.Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands
298.Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, OX3 9DU Oxford, UK; Unit of Genomics of Complex Diseases. Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain
299.Population Health Research Institute,University of London,London,St George's,SW17 0RE,United Kingdom
300.National Heart and Lung Institute,Imperial College London,London,W2 1PG,United Kingdom
301.School of Public Health,Imperial College London,London,W12 7RH,United Kingdom
302.Taichung Veterans General Hospital, Taichung, Taiwan; No. 1650, Sec. 4, Taiwan Boulevard, Xitun District Taichung City 40705, Taiwan; Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; No. 201, Sec. 2, Shipai Road, Beitou District, Taipei City 112201, Taiwan
303.OCDEM, University of Oxford, Churchill Hospital, OX3 7LE Oxford, UK; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK
304.Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore 169857, Singapore
305.Data Science,Singapore Eye Research Institute,Singapore National Eye Centre,168751,Singapore
306.Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., partner site Munich Heart Alliance, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany
307.Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany
308.University of Exeter Medical School,University of Exeter,Exeter,EX2 5DW,United Kingdom
309.Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Sweden
310.Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands
311.Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA
312.Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands
313.Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
314.Department of Genetics,Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,201203,China
315.Wellcome Trust Sanger Institute, CB10 1SA Hinxton, UK; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany
316.Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
317.Institute of Clinical Medicine,Internal Medicine,University of Eastern Finland and Kuopio University Hospital,Kuopio,Finland
318.Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA
319.Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA; Regeneron Pharmaceuticals, Tarrytown, NY, USA
320.Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, W2 1PG London, UK; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
321.Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, UB1 3HW Middlesex, UK; Imperial College Healthcare NHS Trust, Imperial College London, W12 0HS London, UK; National Heart and Lung Institute, Imperial College London, W2 1PG London, UK; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK
322.Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Electrical & Information Engineering, University of the Witwatersrand, Witwatersrand, South Africa
323.Institute for Minority Health Research,University of Illinois College of Medicine,Chicago,United States
324.Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
325.QIMR Berghofer Medical Research Institute,Brisbane,300 Herston Road,QLD 4006,Australia
326.Center for Non-Communicable Diseases, Karachi, SD, Pakistan & Faisalabad Institute of Cardiology, Faislabad, Pakistan; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA
327.Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Big Data Instutute, University of Oxford, OX3 7LF Oxford, UK
328.Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, OX3 7LF Oxford, UK; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK
329.Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine,Medical Science and Nutrition University of Aberdeen,Aberdeen,Foresterhill,AB25 2ZD,United Kingdom
330.Regeneron Pharmaceuticals,Tarrytown,United States
331.Biomedical and Translational Informatics,Geisinger Health,PA 17822,Danville,United States
332.Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA
333.School of Basic and Medical Biosciences,Faculty of Life Sciences and Medicine,King's College London,London,United Kingdom
334.Department of Biomedical Informatics,Vanderbilt University Medical Center,Nashville,United States
335.Departments of Medicine (Medical Genetics) and Genome Sciences,University of Washington,Seattle,United States
336.Center for Autoimmune Genomics and Etiology,Cincinnati Children's Hospital Medical Center (CCHMC),Cincinnati,United States
337.Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Anthropology, Northwestern University, Evanston, IL 60208, USA
338.Department of Public Health and Welfare,Finnish Institute for Health and Welfare,Helsinki,Finland
339.K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger 7600, Norway
340.K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger 7600, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
341.
342.Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
343.Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; Laboratory of Statistical Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan
344.Division of Molecular Pathology,Institute of Medical Science,University of Tokyo,Japan
345.Division of Genome Research,Center for Genome Science,National Institute of Health ,Chungcheongbuk-do,South Korea
346.deCODE genetics/Amgen, Inc., Sturlugata 8, Reykjavik 102, Iceland; Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland
347.VA Boston Healthcare System,Boston,United States
348.VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA; University of Massachusetts, Boston, MA, USA
349.VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA
350.Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
351.VA Boston Healthcare System, Boston, MA, USA; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA
352.Atlanta VA Health Care System, Decatur, GA, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
353.Department of Genetics,University of North Carolina,Chapel Hill,NC 27599,United States
354.Endocrinology, Boston Childrens Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA
355.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA
356.Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
357.Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 75 Ames street, Cambridge, MA 02142, USA; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
358.Centre for Genetics and Genomics Versus Arthritis,Centre for Musculoskeletal Research,Division of Musculoskeletal and Dermatological Sciences,University of Manchester,United Kingdom
359.William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
360.Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
361.VA Palo Alto Health Care Systems, Palo Alto, CA, USA; Department of Statistics, The Pennsylvania State University, University Park, PA, USA; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA; Department of Statistics, Stanford University, Stanford, CA, USA
362.Department of Genetics,Perelman School of Medicine,University of Pennsylvania,Philadelphia,PA 19104,United States
363.
364.

Ramdas，Shweta,Judd，Jonathan,Graham，Sarah E.,et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids[J]. AMERICAN JOURNAL OF HUMAN GENETICS,2022,109(8).

Ramdas，Shweta.,Judd，Jonathan.,Graham，Sarah E..,Kanoni，Stavroula.,Wang，Yuxuan.,...&Brown，Christopher D..(2022).A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.AMERICAN JOURNAL OF HUMAN GENETICS,109(8).

Ramdas，Shweta,et al."A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids".AMERICAN JOURNAL OF HUMAN GENETICS 109.8(2022).