Application of suture anchors for a clinically relevant rat model of rotator cuff tear

Liu，Yang1,2,3,4; Fu，Sai Chuen2,5; Yao，Shi Yi2; Chen，Xiao Dan2; Yung，Patrick Shu Hang2

2022-08-01

10.1002/term.3326

Journal of Tissue Engineering and Regenerative Medicine   影响因子和分区

1932-6254

1932-7005

Current rat model of rotator cuff (RC) tear could not mimic the suture anchor (SA) repair technique in the clinical practice. We designed a novel SA for RC repair of rats to establish a clinically relevant animal model. Small suture anchors that fit the rat shoulder were assembled. 60 rats were assigned to the transosseous (TO) repair group or SA repair group (n = 30/group). Micro-computed tomography (Micro-CT) scanning, biomechanical test and histological analysis were implemented at 2, 4, and 8-week post-repair. The failure load and stiffness in the SA group were significantly higher than those of TO group at 4-week post-repair. Micro-computed tomography analysis showed the bone mineral density and trabecular thickness of the SA group were significantly lower than those of TO group. The SA group showed a better insertion continuity at 4-week post-repair compared to TO group. No significant difference in gait parameters was found between groups. Therefore, SA repair is applicable for the rat model of RC tears. The SA repair achieved superior RC tendon healing, but more extensive initial bone damage compared to TO repair, while the shoulder function was comparable. This model could replicate the current repair technique in the clinical situation and be considered for future preclinical studies on healing enhancement for RC tears. Statement of Clinical Significance: With high clinical relevance, this model may facilitate the translation from an animal study into clinical trials.

animal models rotator cuff injuries suture anchors

SCI ; EI

英语

其他

WOS:000807006800001

20222312203142

Anchors ; Computerized tomography ; Repair

Ship Equipment:671.2 ; Computer Applications:723.5 ; Maintenance:913.5

2-s2.0-85131322398

Scopus

1.Department of Bone and Joint Surgery,Shenzhen People's Hospital,Shenzhen,Guangdong,China
2.Department of Orthopaedics and Traumatology,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong
3.The Second Clinical Medical College,Jinan University,Shenzhen,Guangdong,China
4.The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,China
5.Lui Che Woo Institute of Innovative Medicine,The Chinese University of Hong Kong,Hong Kong

Liu，Yang,Fu，Sai Chuen,Yao，Shi Yi,et al. Application of suture anchors for a clinically relevant rat model of rotator cuff tear[J]. Journal of Tissue Engineering and Regenerative Medicine,2022,16(8):757-770.

Liu，Yang,Fu，Sai Chuen,Yao，Shi Yi,Chen，Xiao Dan,&Yung，Patrick Shu Hang.(2022).Application of suture anchors for a clinically relevant rat model of rotator cuff tear.Journal of Tissue Engineering and Regenerative Medicine,16(8),757-770.

Liu，Yang,et al."Application of suture anchors for a clinically relevant rat model of rotator cuff tear".Journal of Tissue Engineering and Regenerative Medicine 16.8(2022):757-770.