南方科技大学知识苑(SUSTech KC): TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway

题名	TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway
作者	Liu，Huijuan 1; Zhang，Hui 2; Fan，Haidong 1; Tang，Su 1; Weng，Junquan 1
发表日期	2022
DOI	10.1155/2022/1217918
发表期刊	DISEASE MARKERS 影响因子和分区
ISSN	0278-0240
EISSN	1875-8630
卷号	2022
摘要	Background: Transforming growth factor β1-activated kinase 1 binding protein 2 (TAB2) mediates a variety of biological processes through activated nuclear factor κ-light-chain-enhancer of activated B cell (NF-κB) signaling pathways. TAB2 has been reported to be upregulated in a variety of tumors. However, little is known about its potential role in oral squamous cell carcinoma (OSCC). Material and Methods. Patients' clinicopathological and transcription data were obtained from The Cancer Genome Atlas (TCGA) database. Immunohistochemistry staining was used to determine TAB2 expression in OSCC tissues (IHC). The expression of TAB2 in OSCC cell lines was detected by western blotting. The CCK-8 test and flow cytometry assay were utilized to evaluate cell proliferation, apoptosis, and cell cycle in OSCC cell lines. Enrichment analysis and identification of predicted signaling pathways were performed by Gene Ontology and KEGG analysis. Finally, the expression of downstream signal molecules was performed using western blotting to validate the mechanism investigations. Results: TAB2 expression level was aberrantly upregulated in OSCC patients. TAB2 expression was shown to be inversely associated to prognosis. The phenotypic of OSCC cells was considerably impacted by TAB2. OSCC cells with deleted TAB2 exhibit decreased proliferation and increased apoptosis. Additionally, OSCC progression is aided by TAB2 overexpression. Further mechanism studies showed that TAB2 could regulate the progression of OSCC by mediating the upregulation of EMT and PI3K-AKT signaling pathways. Conclusion: This study sheds light on the carcinogenic role of TAB2 in OSCC and provides a potential therapeutic strategy.
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	National Natural Science Foundation of China[81900972] ; Shenzhen Science and Technology Project[JCYJ20210324114200001]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
WOS记录号	WOS:000861847400001
出版者	HINDAWI LTD
ESI学科分类	CLINICAL MEDICINE
Scopus记录号	2-s2.0-85136014377
来源库	Scopus
引用统计	被引频次[WOS]：3
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/382631
专题	南方科技大学第一附属医院
作者单位	1.Department of Stomatology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,518020,China 2.Department of Stomatology,Pingshan District People's Hospital of Shenzhen,Shenzhen,518118,China
第一作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Liu，Huijuan,Zhang，Hui,Fan，Haidong,et al. TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway[J]. DISEASE MARKERS,2022,2022.
APA	Liu，Huijuan,Zhang，Hui,Fan，Haidong,Tang，Su,&Weng，Junquan.(2022).TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.DISEASE MARKERS,2022.
MLA	Liu，Huijuan,et al."TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway".DISEASE MARKERS 2022(2022).