Topographical biointerface regulating cellular functions for bone tissue engineering

Zhu，Mingyu1; Zhang，Rui2; Mao，Zhixiang1; Fang，Ju1; Ren，Fuzeng1

2022

10.1049/bsb2.12043

Biosurface and Biotribology   影响因子和分区

2405-4518

2405-4518

The physiochemical properties of the implant interface significantly influence cell growth, differentiation, cellular matrix deposition, and mineralisation, and eventually, determine the bone regeneration efficiency. Cells directly sense and respond to the physical, chemical, and mechanical cues of the implant surface, and it is increasingly recognized that surface topography can evoke specific cellular responses, conferring biological functions on substrate materials and regulating tissue regeneration. Current progress towards the fundamental understanding of the interplay between the cell and topographical surface has been made by combined advance in fabrication technologies and cell biology. Particularly, the precise fabrication and control of nano/microscale topographies can provide the fundamental knowledge of the mechanotransduction process that governs the cellular response as well as the knowledge of how the specific features drive cells towards a defined differentiation outcome. In this review, we first introduce common techniques and substrate materials for designing and fabricating micro/nano-topographical surfaces for bone regeneration. We then illustrate the intrinsic relationship of topological cues, cellular signal transduction, and cell functions and fates in osteogenic differentiation. Finally, we discuss the challenges and the future of using topological cues as a cell therapy to direct bone tissue regeneration.

EI ; ESCI

英语

第一 ; 通讯

This work was financially supported by the National Natural Science Foundation of China (Grant No. 52122102), the Natural Science Foundation of Guangdong (No. 2019A1515011755) and the Fundamental Research Program of Shenzhen (Grant No. JCYJ2019080914040165[52122102] ; National Natural Science Foundation of China[2019A1515011755] ; Natural Science Foundation of Guangdong[JCYJ20190809140401658]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001108334600007

WILEY

20223412595564

Bone ; Cell proliferation ; Signal transduction ; Topography ; Topology

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Combinatorial Mathematics, Includes Graph Theory, Set Theory:921.4 ; Materials Science:951

2-s2.0-85135897478

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China
2.Department of Prosthodontics,Stomatology Center,Peking University Shenzhen Hospital,Shenzhen,Guangdong,China

Zhu，Mingyu,Zhang，Rui,Mao，Zhixiang,et al. Topographical biointerface regulating cellular functions for bone tissue engineering[J]. Biosurface and Biotribology,2022,8(3):165-187.

Zhu，Mingyu,Zhang，Rui,Mao，Zhixiang,Fang，Ju,&Ren，Fuzeng.(2022).Topographical biointerface regulating cellular functions for bone tissue engineering.Biosurface and Biotribology,8(3),165-187.

Zhu，Mingyu,et al."Topographical biointerface regulating cellular functions for bone tissue engineering".Biosurface and Biotribology 8.3(2022):165-187.