核酸修饰的有机功能材料的合成与应用

SYNTHESIS AND APPLICATION OF NUCLEIC ACID MODIFIED ORGANIC FUNCTIONAL MATERIALS

翟士尧

11749105

硕士

材料学

田雷蕾

2019-05-24

2019-07-10

哈尔滨工业大学

深圳

DNA具有特异性的分子识别和对刺激信号响应的特性，在生物传感、纳米医药、智能材料领域有广泛的应用。将DNA分子的识别和响应转换成可读取和量化的信号，需要将DNA和具有光、电、磁等特性的材料相结合。其中DNA和无机功能纳米材料的共价接枝技术已经相对成熟，但和有机功能材料的共价接枝还有比较大的局限性，特别是对于疏水性较强的有机材料，接枝的方法仍需探索。

DNA has a wide range of applications in biosensing, nanomedicine, and smart materials due to its specific molecular recognition and stimuli-responsive properties. In order to detect and quantify the recognition and responsiveness of DNA to targets, materials with optical, electrical, and magnetic properties have to be connected with DNA. The covalent grafting technology of DNA and inorganic functional nanomaterials has been well developed. However, covalent conjugation between DNA and organic functional materials still has many problems, especially for very hydrophobic organic materials, which needs further exploration.

生物传感器 DNA共价接枝 有机共轭小分子 纳米诊疗平台 点击化学

Biosensor DNA conjugation Organic conjugated small molecule Nano-diagnostic platform Click coupling

中文

联合培养

南方科技大学

翟士尧. 核酸修饰的有机功能材料的合成与应用[D]. 深圳. 哈尔滨工业大学,2019.