过渡金属催化酮直接不对称还原胺化合成伯胺及其衍生物

TRANSITION METAL-CATALYZED DIRECT ASYMMETRIC REDUCTIVE AMINATION OF KETONES FOR THE SYNTHESIS OF PRIMARY AMINES AND THEIR DERIVATIVES

高爽

11749052

硕士

化学

张绪穆

2019-05-25

2019-07-10

哈尔滨工业大学

深圳

手性胺类化合物广泛存在于天然产物和药物分子中，高效制备各种手性胺是现代化学研究的热点问题。过渡金属催化还原胺化反应可以将酮类化合物直接转化为手性胺，是目前构建手性胺类化合物最为高效的方法之一。近些年来，过渡金属催化的不对称还原胺化反应受到了广泛的关注，并取得了很大的进展，但总体而言，依然存在着催化体系不够高效直接，底物范围受限等挑战，发展新的催化体系用于酮的不对称还原胺化反应十分有必要。

Chiral amines are widely existed in natural products and drugs. The efficient preparation of various chiral amines is a hot topic in modern organic chemistry. Transition metal-catalyzed reductive amination can directly convert ketones into chiral amines, which is one of the most efficient methods to construct chiral amines. In recent years, asymmetric reductive amination catalyzed by transition metals has aroused extensive attention and considerable progress has also been achieved. However, significant challenges, such as the lack of highly efficient catalytic system and limited substrate scope, remain to be solved. Thus, it is necessary to develop new catalytic systems for asymmetric reductive amination of ketones. 

还原胺化 芳基烷基酮 手性胺 内酰胺 串联

reductive amination aryl alkyl ketones chiral amine lactam cascade

中文

联合培养

南方科技大学

高爽. 过渡金属催化酮直接不对称还原胺化合成伯胺及其衍生物[D]. 深圳. 哈尔滨工业大学,2019.