人源P53与COP1/DET1复合物表达纯化以及相互作用研究

The Expression, Purification and Interaction Studies of Human P53 and COP1/DET1 Complex

刘健博

11749068

硕士

生物学

汪涛

2019-05-30

2019-06-20

哈尔滨工业大学

深圳

肿瘤时刻威胁着人类的生命，寻找治愈肿瘤的方法一直是人类健康科学最重要的研究内容。肿瘤抑癌基因p53在肿瘤的发生、发展和调控中起着异常重要的作用，在许多重要的细胞信号通路中，p53可以激活抑癌基因的表达从而抑制肿瘤的发生，而p53基因的突变、缺失或减少常常导致细胞内信号通路发生紊乱，从而引发细胞生长失控并发生癌变。由于p53基因在肿瘤中具有相当高的突变频率，因此针对p53的靶向研究是治疗肿瘤的重要研究方向。

Tumors are always threatening of human life. Finding a cure for tumors has always been the most important research content of human health science. Tumor suppressor gene p53 plays an extremely important role in the occurrence, development and regulation of tumors. In many significant cell signaling pathways, p53 can activate the expression of tumor suppressor genes and thus inhibit the occurrence of tumors, and the mutation, deletion or reduction of p53 gene often leads to the disorder of intracellular signaling pathways, resulting in cell growing out of control and becoming cancerous. Because of the high mutation frequency of p53 gene in tumors, the targeted study on p53 is an important research field for the treatment of tumors.

p53 COP1 DET1 表达 纯化 相互作用

P53 COP1 DET1 expression purification interaction

中文

联合培养

南方科技大学

刘健博. 人源P53与COP1/DET1复合物表达纯化以及相互作用研究[D]. 深圳. 哈尔滨工业大学,2019.