| 题名 | YT521-B homology domain family proteins as N6-methyladenosine readers in tumors |
| 作者 | |
| 通讯作者 | Zhu, Lizhi; Zheng, Duo |
| 发表日期 | 2022-08-09
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| DOI | |
| 发表期刊 | |
| EISSN | 1664-8021
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| 卷号 | 13 |
| 摘要 | N6-methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic mRNA and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma, through varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, epithelial-mesenchymal transition (EMT), immune escape, and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and its function in tumor progression. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 非南科大
|
| 资助项目 | [2021A1515011154]
; [2019A1515010210]
; [2021A1515011046]
; [2021A1515010996]
; [2019B1515120080]
; [JCYJ20210324093408024]
; [JCYJ20180507182427559]
; [SZXK060]
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| WOS研究方向 | Genetics & Heredity
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| WOS类目 | Genetics & Heredity
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| WOS记录号 | WOS:000844331600001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：2
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/394193 |
| 专题 | 南方科技大学 |
| 作者单位 | 1.Shenzhen Univ, Guangdong Prov Key Lab Genome Stability & Dis Prev, Int Canc Ctr, Dept Cell Biol & Genet,Sch Med,Dept Pharm,Affiliat, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Yantain Hosp, Cent Lab, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Yang, Heng,Chiang, Chengyao,Luo, Qinhong,et al. YT521-B homology domain family proteins as N6-methyladenosine readers in tumors[J]. FRONTIERS IN GENETICS,2022,13.
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| APA |
Yang, Heng.,Chiang, Chengyao.,Luo, Qinhong.,Chen, Chunlan.,Huang, Junrong.,...&Zheng, Duo.(2022).YT521-B homology domain family proteins as N6-methyladenosine readers in tumors.FRONTIERS IN GENETICS,13.
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| MLA |
Yang, Heng,et al."YT521-B homology domain family proteins as N6-methyladenosine readers in tumors".FRONTIERS IN GENETICS 13(2022).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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