南方科技大学知识苑(SUSTech KC): Integrated single-cell analyses decode the developmental landscape of the human fetal spine

题名	Integrated single-cell analyses decode the developmental landscape of the human fetal spine
作者	Yu, Haiyan 1,2; Tang, Donge 1; Wu, Hongwei 1; Li, Chunhong 1; Lu, Yongping 1,3; He, Fang 4; Zhang, Xiaogang 4; Yang, Yane 5; Shi, Wei6 ; Hu, Wenlong 1; Zeng, Zhipeng 1; Dai, Weier 7; Ou, Minglin 8; Dai, Yong 1
通讯作者	Ou, Minglin; Dai, Yong
发表日期	2022-07-15
DOI	10.1016/j.isci.2022.104679
发表期刊	ISCIENCE 影响因子和分区
EISSN	2589-0042
卷号	25 期号:7
摘要	The spine has essential roles in supporting body weight, and passaging the neural elements between the body and the brain. In this study, we used integrated sin-gle-cell RNA sequencing and single-cell transposase-accessible chromatin sequencing analyses to reveal the cellular heterogeneity, lineage, and transcrip-tional regulatory network of the developing human spine. We found that EPYC + HAPLN1+ fibroblasts with stem cell characteristics could differentiate into chondrocytes by highly expressing the chondrogenic markers SOX9 and MATN4. Neurons could originate from neuroendocrine cells, and MEIS2 may be an essential transcription factor that promotes spinal neural progenitor cells to selectively differentiate into neurons during early gestation. Furthermore, the interaction of NRP2_SEMA3C and CD74_APP between macrophages and neu-rons may be essential for spinal cord development. Our integrated map provides a blueprint for understanding human spine development in the early and midges-tational stages at single-cell resolution and offers a tool for investigating related diseases.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Science and Technology Planning Project of Guangdong Province, China[2021A1515111071] ; Guangdong Provincial Clinical Research Center for Birth Defects[2017B 020209001]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000838442800009
出版者	CELL PRESS
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/394196
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2,Affiliated Hosp 1,Clin Med Res Ct, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Med Univ, Shenzhen Pingshan Dist Peoples Hosp, Dept Pharm, Pingshan Gen Hosp, Shenzhen 518118, Guangdong, Peoples R China 3.Jinan Univ, Affiliated Hosp 1, Inst Nephrol & Blood Purificat, Guangzhou 510632, Peoples R China 4.Singleron Biotechnol, Yaogu Ave 11, Nanjing, Jiangsu, Peoples R China 5.Shenzhen East Women & Children Hosp, Shenzhen 518000, Guangdong, Peoples R China 6.Southern Univ Sci & Technol, Jinan Univ, Clin Med Coll 2, Dept Obstet & Gynecol,Affiliated Hosp 1,Shenzhen, Shenzhen 518020, Guangdong, Peoples R China 7.Univ Texas Austin, Coll Nat Sci, Austin, TX 78721 USA 8.Guilin Med Univ, Cent Lab, Affiliated Hosp 2, 212 Renmin Rd, Guilin 541000, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yu, Haiyan,Tang, Donge,Wu, Hongwei,et al. Integrated single-cell analyses decode the developmental landscape of the human fetal spine[J]. ISCIENCE,2022,25(7).
APA	Yu, Haiyan.,Tang, Donge.,Wu, Hongwei.,Li, Chunhong.,Lu, Yongping.,...&Dai, Yong.(2022).Integrated single-cell analyses decode the developmental landscape of the human fetal spine.ISCIENCE,25(7).
MLA	Yu, Haiyan,et al."Integrated single-cell analyses decode the developmental landscape of the human fetal spine".ISCIENCE 25.7(2022).