南方科技大学知识苑(SUSTech KC): Ameliorating Alzheimer's-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling

题名	Ameliorating Alzheimer's-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling
作者	Zhao, Yu1 ; Wang, Chuanling 2,3,4; He, Wenbo 4; Cai, Zhiyou 2,3
通讯作者	Zhao, Yu; Cai, Zhiyou
发表日期	2022
DOI	10.2174/1570159X19666211202124925
发表期刊	Current Neuropharmacology 影响因子和分区
ISSN	1570-159X
EISSN	1875-6190
卷号	20 期号:9
摘要	Background: Minocycline has multiple neuroprotective roles in abundant brain diseases, including the prevention and treatment of Alzheimer's disease (AD). Cdk5/p25 signaling plays an important role in the onset and development of Alzheimer's-like pathology. The aim of the present work was to further explore the underlying mechanism which minocycline effects on Cdk5/p25 signaling related to Alzheimer's-like pathology. Methods: The cognitive function of animals was measured by the Morris water maze test. The levels of A beta were determined by an enzyme-linked immunosorbent assay. The levels of APP, beta- and gamma-secretases, and the biomarkers of tau (total tau and hyperphosphorylated tau), inflammatory cytokine and matrix metalloproteinases (MMP-2 and MMP-9), and biomarkers of synapse and Cdk5/p25 signaling, were detected by the Western blotting. The biomarkers of the synapse, inflammatory cytokine, and matrix metalloproteinases (MMP-2 and MMP-9) were also determined by immunofluorescence. Results: Minocycline improved learning and memory in APP/PS1 mice. It limited the production of A beta and hyperphosphorylation of tau in the hippocampus and ameliorated synaptic deficit. Moreover, it also inhibited the activation of Cdk5/p25 signaling, inflammation, and matrix metalloproteinases. Conclusion: Minocycline mitigates Alzheimer's-like pathology via limiting the activation of Cdk5/p25 signaling pathway and improves cognitive deficits.
关键词	Minocycline Alzheimer's disease pathology synapse cyclin-dependent kinase 5 anti-inflammatory drugs
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Chongqing Natural Science Foundation[cstc2018jcyjA4051] ; Chongqing Health and Natural Science Foundation[2018ZDXM004] ; Natural Science Foundation of Hubei Province[2015 CFB260] ; Hubei Province Health and Family Planning Scientific Research Project[WJ2015MB219] ; Shiyan Natural Science Foundation[15K70]
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
WOS类目	Neurosciences ; Pharmacology & Pharmacy
WOS记录号	WOS:000843817800012
出版者	BENTHAM SCIENCE PUBL LTD
来源库	Web of Science
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/394236
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Dept Neurol, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China 2.Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China 3.Chongqing Key Lab Neurodegenerat Dis, Chongqing 400013, Peoples R China 4.Hubei Univ Med, Renmin Hosp, Shiyan Renmin Hosp, Dept Neurol, Shiyan 442000, Hubei, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhao, Yu,Wang, Chuanling,He, Wenbo,et al. Ameliorating Alzheimer's-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling[J]. Current Neuropharmacology,2022,20(9).
APA	Zhao, Yu,Wang, Chuanling,He, Wenbo,&Cai, Zhiyou.(2022).Ameliorating Alzheimer's-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling.Current Neuropharmacology,20(9).
MLA	Zhao, Yu,et al."Ameliorating Alzheimer's-like Pathology by Minocycline via Inhibiting Cdk5/p25 Signaling".Current Neuropharmacology 20.9(2022).