New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development

Aizezi, Yalikunjiang1,2; Xie, Yinpeng1,2; Guo, Hongwei1,2; Jiang, Kai1,2

2022-08-01

10.3390/life12081285

LIFE-BASEL   影响因子和分区

2075-1729

The apical hook is formed by dicot seedlings to protect the tender shoot apical meristem during soil emergence. Regulated by many phytohormones, the apical hook has been taken as a model to study the crosstalk between individual signaling pathways. Over recent decades, the roles of different phytohormones and environmental signals in apical hook development have been illustrated. However, key regulators downstream of canonical hormone signaling have rarely been identified via classical genetics screening, possibly due to genetic redundancy and/or lethal mutation. Chemical genetics that utilize small molecules to perturb and elucidate biological processes could provide a complementary strategy to overcome the limitations in classical genetics. In this review, we summarize current progress in hormonal regulation of the apical hook, and previously reported chemical tools that could assist the understanding of this complex developmental process. We also provide insight into novel strategies for chemical screening and target identification, which could possibly lead to discoveries of new regulatory components in apical hook development, or unidentified signaling crosstalk that is overlooked by classical genetics screening.

chemical genetics phytohormones apical hook development Auxin Polar auxin transport

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China["21,907,049","31911540070"] ; Guangdong Innovative and Entrepreneurial Research Team Program[2016ZT06S172] ; Shenzhen Science and Technology Program["KYTDPT20181011104005","KQTD20190929173906742"]

Life Sciences & Biomedicine - Other Topics ; Microbiology

Biology ; Microbiology

WOS:000845569700001

MDPI

Web of Science

1.Southern Univ Sci & Technol SUSTech, Inst Plant & Food Sci, Sch Life Sci, Dept Biol, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Key Lab Mol Design Plant Cell Factory Guangdong H, Shenzhen 518055, Peoples R China

Aizezi, Yalikunjiang,Xie, Yinpeng,Guo, Hongwei,et al. New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development[J]. LIFE-BASEL,2022,12(8).

Aizezi, Yalikunjiang,Xie, Yinpeng,Guo, Hongwei,&Jiang, Kai.(2022).New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development.LIFE-BASEL,12(8).

Aizezi, Yalikunjiang,et al."New Wine in an Old Bottle: Utilizing Chemical Genetics to Dissect Apical Hook Development".LIFE-BASEL 12.8(2022).