南方科技大学知识苑(SUSTech KC): Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair

题名	Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair
作者	Wu，Guofeng 1,2,3; Ma，Fenbo3 ; Liu，Zhengwei1,3 ; Liu，Jiayi3 ; Xue，Yizhebang3 ; Zhang，Mengdi 5; Wen，Chunyi 6; Tang，Bin3,4 ; Lin，Lijun 1
通讯作者	Tang，Bin; Lin，Lijun
发表日期	2022-11-01
DOI	10.1016/j.ijbiomac.2022.08.071
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 影响因子和分区
ISSN	0141-8130
EISSN	1879-0003
卷号	220页码:1104-1113
摘要	The alteration of the extracellular matrix (ECM) homeostasis plays an important role in the development of osteoarthritis (OA). The pathological changes of OA are mainly manifested in the large reduction of components in ECM, like type II collagen and aggrecan, especially hyaluronic acid and chondroitin sulfate and often accompanied by inflammation. Rebuilding ECM and inhibiting inflammation may reverse OA progression. In this work, we developed new magnesium-containing glycosaminoglycans (Mg-GAGs), to create a positive ECM condition for promoting cartilage regeneration and alleviating OA. In vitro results suggested that the introduction of Mg-GAGs contributed to promoting chondrocyte proliferation and facilitated upregulating chondrogenic genes and suppressed inflammation-related factors. Moreover, Mg-GAGs exhibited positive effects on suppressing synovial inflammation, reducing chondrocyte apoptosis and preserving the subchondral bone in the ACLT-induced OA rabbit model. This study provides new insight into ECM-based therapeutic strategy and opens a new avenue for the development of novel OA treatment.
关键词	Extracellular matrix Glycosaminoglycans Magnesium
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	National Key Research and Development Program of China[2019YFA0906004];
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:000857295600003
出版者	ELSEVIER
ESI学科分类	BIOLOGY & BIOCHEMISTRY
Scopus记录号	2-s2.0-85136653586
来源库	Scopus
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/394998
专题	南方科技大学医院工学院_生物医学工程系
作者单位	1.Department of Joint and Orthopedics,Zhujiang Hospital,Southern Medical University,Guangzhou,Guangdong,China 2.Department of Orthopedics,Southern University of Science and Technology Hospital,Shenzhen,Guangdong,China 3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China 4.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,China 5.Department of Sports Medicine,Peking University Shenzhen Hospital,Shenzhen,Guangdong,China 6.Department of Biomedical Engineering,Faculty of Engineering,The Hong Kong Polytechnic University,Kowloon,Hong Kong
第一作者单位	南方科技大学医院; 生物医学工程系
通讯作者单位	生物医学工程系
推荐引用方式 GB/T 7714	Wu，Guofeng,Ma，Fenbo,Liu，Zhengwei,et al. Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2022,220:1104-1113.
APA	Wu，Guofeng.,Ma，Fenbo.,Liu，Zhengwei.,Liu，Jiayi.,Xue，Yizhebang.,...&Lin，Lijun.(2022).Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,220,1104-1113.
MLA	Wu，Guofeng,et al."Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 220(2022):1104-1113.