AGreen and Wide-Scope Approach for Chiroptical Sensing of Organic Molecules through Biomimetic Recognition in Water

Wang，Li Li; Quan，Mao; Yang，Ti Long; Chen，Zhao; Jiang，Wei

2020

10.1002/ANGE.202011566

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

Optical chirality sensing has attracted a lot of interest due to its potential in high-throughput screening in chirality analysis. A molecular sensor is required to convert the chirality of analytes into optical signals. Although many molecular sensors have been reported, sensors with wide substrate scope remain to be developed. Herein, we report that the amide naphthotube-based chirality sensors have an unprecedented wide scope for chiroptical sensing of organic molecules. The substrates include, but are not limited to common organic products in asymmetric catalysis, chiral molecules with inert groups or remote functional groups from their chiral centers, natural products and their derivatives, and chiral drugs. The effective chirality sensing is based on biomimetic recognition in water and on effective chirality transfer through guest-induced formation of a chiral conformation of the sensors. Furthermore, the sensors can be used in real-time monitoring on reaction kinetics in water and in determining absolute configurations and ee values of the products in asymmetric catalysis.

biomimetic recognition chiral molecules chirality sensing molecular recognition naphthotube

EI

英语

第一 ; 通讯

20223412618013

Amides ; Biomimetics ; Catalysis ; Molecules ; Reaction kinetics ; Stereochemistry ; Substrates

Biotechnology:461.8 ; Biology:461.9 ; Chemistry:801 ; Chemical Reactions:802.2 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

MATERIALS SCIENCE

2-s2.0-85097007015

Scopus

Shenzhen Grubbs Institute,Guangdong Provincial Key Laboratory of Catalysis,Department of Chemistry,Southern University of Science and Technology,Shenzhen,Xueyuan Blvd 1088,518055,China

Wang，Li Li,Quan，Mao,Yang，Ti Long,et al. AGreen and Wide-Scope Approach for Chiroptical Sensing of Organic Molecules through Biomimetic Recognition in Water[J]. ADVANCED MATERIALS,2020,132(52):24025-24032.

Wang，Li Li,Quan，Mao,Yang，Ti Long,Chen，Zhao,&Jiang，Wei.(2020).AGreen and Wide-Scope Approach for Chiroptical Sensing of Organic Molecules through Biomimetic Recognition in Water.ADVANCED MATERIALS,132(52),24025-24032.

Wang，Li Li,et al."AGreen and Wide-Scope Approach for Chiroptical Sensing of Organic Molecules through Biomimetic Recognition in Water".ADVANCED MATERIALS 132.52(2020):24025-24032.