南方科技大学知识苑(SUSTech KC): Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect

题名	Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect
作者	Jing，Di 1,2; Jiang，Nian 5; Wang，Fengyi3 ; Mao，Chunping 3; Han，Shujun 4; Ho，Pui Yan 1; Xiao，Wenwu 1; Li，Yuanpei 1; Li，Jian Jian 4; Zhang，Lu3 ; Lam，Kit S.1,6
通讯作者	Zhang，Lu; Lam，Kit S.
发表日期	2022-10-01
DOI	10.1016/j.biomaterials.2022.121769
发表期刊	BIOMATERIALS 影响因子和分区
ISSN	0142-9612
EISSN	1878-5905
卷号	289
摘要	Low dose non-toxic disulfide cross-linked micelle (DCM) encapsulated paclitaxel (PTX) was found to be highly efficacious as a radiosensitizer against oral cancer preclinical model. Intensity-modulated radiation therapy was locally administered for three consecutive days 24 h after intravascular injection of DCM-[PTX] at 5 mg/kg PTX. DCM-[PTX] NPs combined with conventional radiotherapy (2 Gy) resulted in a 1.7-fold improvement in therapeutic efficacy compared to conventional PTX plus radiotherapy. Interestingly, we found that radiotherapy can decrease tight junctions and increase the accumulation of DCM-[PTX] in tumor sites. Stereotactic body radiotherapy (SBRT) given at 6 Gy was used to further investigate the synergistic anti-tumor effect. Tumor tissues were collected to analyze the relationship between the time interval after SBRT and the biodistribution of the nanomaterials. Compared to combination DCM-[PTX] with conventional radiation dose, combination DCM-PTX with SBRT was found to be more efficacious in inhibiting tumor growth.
关键词	Nano-micelle Oral cancer Radio-sensitizer Radiotherapy
相关链接	[Scopus记录]
收录类别	SCI ; EI
语种	英语
学校署名	通讯
资助项目	NIH of United States Grants["R01CA115483","U01CA198880","R01CA247683"] ; Hunan Provincial Natural Science Foundation of China[2022JJ30933]
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000860790100002
出版者	ELSEVIER SCI LTD
EI入藏号	20223612702583
EI主题词	Diseases ; Dosimetry ; Micelles ; Sulfur compounds ; Tumors
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Radioactive Material Applications:622.3 ; Colloid Chemistry:801.3 ; Radiation Measurements:944.8
ESI学科分类	MATERIALS SCIENCE
Scopus记录号	2-s2.0-85137156136
来源库	Scopus
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/401607
专题	工学院_生物医学工程系
作者单位	1.Department of Biochemistry and Molecular Medicine,UC Davis Comprehensive Cancer Center,University of California Davis,Sacramento,United States 2.Department of Oncology,National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan,China 3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,China 4.Department of Radiation Oncology,School of Medicine,University of California Davis,Sacramento,United States 5.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,China 6.Division of Hematology and Oncology,Department of Internal Medicine,School of Medicine,University of California Davis,Sacramento,United States
通讯作者单位	生物医学工程系
推荐引用方式 GB/T 7714	Jing，Di,Jiang，Nian,Wang，Fengyi,et al. Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect[J]. BIOMATERIALS,2022,289.
APA	Jing，Di.,Jiang，Nian.,Wang，Fengyi.,Mao，Chunping.,Han，Shujun.,...&Lam，Kit S..(2022).Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect.BIOMATERIALS,289.
MLA	Jing，Di,et al."Nanoradiosensitizer with good tissue penetration and enhances oral cancer radiotherapeutic effect".BIOMATERIALS 289(2022).