| 题名 | Neisseria species as pathobionts in bronchiectasis |
| 作者 | Li，Liang1,2  ; Mac Aogáin，Micheál3,4,5; Xu，Tengfei6,7; Jaggi，Tavleen Kaur3; Chan，Louisa L.Y.3; Qu，Jing2; Wei，Lan2; Liao，Shumin2; Cheng，Hong Sheng3; Keir，Holly R.8; Dicker，Alison J.8; Tan，Kai Sen9; De Yun，Wang9; Koh，Mariko Siyue10; Ong，Thun How10; Lim，Albert Yick Hou11; Abisheganaden，John A.3,11; Low，Teck Boon12; Hassan，Tidi Maharani13; Long，Xiang14; Wark，Peter A.B.15,16; Oliver，Brian17,18; Drautz-Moses，Daniela I.19; Schuster，Stephan C.19; Tan，Nguan Soon3,20; Fang，Mingliang6,21; Chalmers，James D.8; Chotirmall，Sanjay H.3,11
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| 通讯作者 | Chotirmall，Sanjay H. |
| 发表日期 | 2022-09-14
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| DOI | |
| 发表期刊 | |
| ISSN | 1931-3128
|
| EISSN | 1934-6069
|
| 卷号 | 30期号:9页码:1311-1327.e8 |
| 摘要 | Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 第一
|
| 资助项目 | Natural Science Foundation of Guangdong Province[2021A1515010004]
; National Natural Science Foundation of China[81900071]
; National Medical Research Council[MOH-000141]
; National Medical Research Council[MOH-000710]
|
| WOS研究方向 | Microbiology
; Parasitology
; Virology
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| WOS类目 | Microbiology
; Parasitology
; Virology
|
| WOS记录号 | WOS:000889279600003
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85137627517
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：37
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/401616 |
| 专题 | 南方科技大学医学院_药理学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China 2.Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China 3.Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore,Singapore 4.Biochemical Genetics Laboratory,Department of Biochemistry,St. James's Hospital,Dublin,Ireland 5.Clinical Biochemistry Unit,School of Medicine,Trinity College Dublin,Dublin,Ireland 6.School of Civil and Environmental Engineering,Nanyang Technological University,Singapore,Singapore 7.College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China 8.University of Dundee,Ninewells Hospital,Medical School,Dundee,United Kingdom 9.Department of Otolaryngology,Infectious Disease Translational Research Programme,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore 10.Department of Respiratory and Critical Care Medicine,Singapore General Hospital,Singapore,Singapore 11.Department of Respiratory and Critical Care Medicine,Tan Tock Seng Hospital,Singapore,Singapore 12.Department of Respiratory and Critical Care Medicine,Changi General Hospital,Singapore,Singapore 13.Universiti Kebangsaan Malaysia,Kuala Lumpur,Malaysia 14.Department of Respiratory Medicine and Critical Care,Peking University Shenzhen Hospital,Shenzhen,China 15.Priority Research Centre for Healthy Lungs,Hunter Medical Research Institute,School of Medicine and Public Health,University of Newcastle,Newcastle,Australia 16.Department of Respiratory and Sleep Medicine,John Hunter Hospital,New Lambton Heights,Australia 17.Woolcock Institute of Medical Research,University of Sydney,Sydney,Australia 18.School of Life Sciences,University of Technology Sydney,Sydney,Australia 19.Singapore Centre for Environmental Life Sciences Engineering (SCELSE),Nanyang Technological University,Singapore,Singapore 20.School of Biological Sciences,Nanyang Technological University,Singapore,Singapore 21.Department of Environmental Science and Engineering,Fudan University,Shanghai,200433,China |
| 第一作者单位 | 药理学系; 南方科技大学医学院 |
| 第一作者的第一单位 | 药理学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Li，Liang,Mac Aogáin，Micheál,Xu，Tengfei,et al. Neisseria species as pathobionts in bronchiectasis[J]. Cell Host & Microbe,2022,30(9):1311-1327.e8.
|
| APA |
Li，Liang.,Mac Aogáin，Micheál.,Xu，Tengfei.,Jaggi，Tavleen Kaur.,Chan，Louisa L.Y..,...&Chotirmall，Sanjay H..(2022).Neisseria species as pathobionts in bronchiectasis.Cell Host & Microbe,30(9),1311-1327.e8.
|
| MLA |
Li，Liang,et al."Neisseria species as pathobionts in bronchiectasis".Cell Host & Microbe 30.9(2022):1311-1327.e8.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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