| 题名 | Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease |
| 作者 | |
| 通讯作者 | Yao，Jun |
| 发表日期 | 2022
|
| DOI | |
| 发表期刊 | |
| ISSN | 1176-9114
|
| EISSN | 1178-2013
|
| 卷号 | 17页码:3893-3911 |
| 摘要 | The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane vesicles (OMVs), have unique structure/composition/morphology characteristics, and show excellent physical and chemi-cal/biochemical properties, making them a new generation of theranostic nanomedicine. Here, we reviewed the characteristics of EVs from the perspective of their formation and biological function in inflammatory bowel disease (IBD). Moreover, EVs can crucially participate in the interaction and communication of intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, intestinal inflammation and intestinal homeostasis. Interestingly, based on current representative examples in the field of exosomes and exosome-like nanoparticles for IBD treatment, it is shown that plant, milk, and cells-derived exosomes and exosome-like nanoparticles can exert a therapeutic effect through their components, such as proteins, nucleic acid, and lipids. Moreover, several drug loading methods and target modification of exosomes are used to improve their therapeutic capability. We also discussed the application of exosomes and exosome-like nanoparticles in the treatment of IBD. In this review, we aim to better and more clearly clarify the underlying mechanisms of the EVs in the pathogenesis of IBD, and provide directions of exosomes and exosome-like nanoparticles mediated for IBD treatment. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 第一
; 通讯
|
| 资助项目 | National Natural Science Foundation of China[81800489];
|
| WOS研究方向 | Science & Technology - Other Topics
; Pharmacology & Pharmacy
|
| WOS类目 | Nanoscience & Nanotechnology
; Pharmacology & Pharmacy
|
| WOS记录号 | WOS:000854413100001
|
| 出版者 | |
| Scopus记录号 | 2-s2.0-85137528261
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：32
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/401657 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Department of Gastroenterology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China 2.Department of Hematology,Shenzhen,Yantian District People’s Hospital,China 3.Department of Gastroenterology and Hepatology,Guangzhou Digestive Disease Center,Guangzhou First People’s Hospital (School of Medicine of South China University of Technology),Guangzhou,China 4.Department of Child and Adolescent Psychiatry,Shenzhen Kangning Hospital,Shenzhen,China 5.Department of Medical Administration,Huizhou Institute of Occupational Diseases Control and Prevention,Huizhou,China 6.Department of Emergency,Shenzhen People’s Hospital,(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 第一作者的第一单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Li，De Feng,Yang，Mei Feng,Xu，Jing,et al. Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease[J]. International Journal of Nanomedicine,2022,17:3893-3911.
|
| APA |
Li，De Feng.,Yang，Mei Feng.,Xu，Jing.,Xu，Hao Ming.,Zhu，Min Zheng.,...&Yao，Jun.(2022).Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease.International Journal of Nanomedicine,17,3893-3911.
|
| MLA |
Li，De Feng,et al."Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease".International Journal of Nanomedicine 17(2022):3893-3911.
|
| 条目包含的文件 | 条目无相关文件。 | |||||
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