Assessing hemorrhagic shock: Feasibility of using an ultracompact photoacoustic microscope

Chen，Qian1,2; Guo，Heng1,2; Qi，Weizhi1,2; Gan，Qi3; Yang，Lei4; Ke，Bowen4; Chen，Xingxing2; Jin，Tian1,2; Xi，Lei1,2

2019-04-01

英语

National Natural Science Foundation of China[61528401];National Natural Science Foundation of China[61775028];National Natural Science Foundation of China[81571722];

Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate. Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics in microcirculation. Here, we propose an ultracompact photoacoustic microscope to assess hemorrhagic shock using a rat model and demonstrate its clinical feasibility by visualizing buccal microcirculation of healthy volunteers. Both functional and morphological features of the microvascular network including concentration of total hemoglobin (C ), number of blood vessels (VN), small vascular density (SVD) and vascular diameter (VD) were derived to assess the microvascular hemodynamics of different organs. Animal studies show the feasibility of the proposed tool to assess and stage the hemorrhagic shock via microcirculation. in vivo oral imaging of healthy volunteers indicates the translational possibility of this technique for clinical evaluation of hemorrhagic shock.

10.1002/jbio.201800348

Journal of Biophotonics

12

4

1864-063X

SCI ; EI

第一 ; 通讯

2-s2.0-85058366092

Scopus

WOS:000464399800022

20185106256291

Photoacoustic microscopy ; Blood vessels

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Imaging Techniques:746

1864-0648

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,China
2.School of Physics,University of Electronic Science and Technology of China,Chengdu,China
3.Department of Neurosurgery,West China Hospital Sichuan University,Chengdu,China
4.Department of Anesthesiology and Critical Care Medicine,West China Hospital Sichuan University,Chengdu,China

Chen，Qian,Guo，Heng,Qi，Weizhi,et al. Assessing hemorrhagic shock: Feasibility of using an ultracompact photoacoustic microscope. 2019-04-01.