南方科技大学知识苑(SUSTech KC): Nonviral Delivery of CRISPR/Cas Systems in mRNA Format

题名	Nonviral Delivery of CRISPR/Cas Systems in mRNA Format
作者	Liu, Zhen 1 ; Li, Zhenghua 1; Li, Bin 1,2
通讯作者	Li, Bin
发表日期	2022-09-01
DOI	10.1002/anbr.202200082
发表期刊	ADVANCED NANOBIOMED RESEARCH 影响因子和分区
ISSN	2699-9307
摘要	The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) genome editing system provides a powerful toolbox for genetic engineering. However, safe and efficient in vivo delivery of all CRISPR components into the nuclei of target organs remains challenging toward CRISPR/Cas clinical translation. With the rapid development of nanotechnology, the nonviral CRISPR/Cas mRNA delivery systems are emerging as one of the most clinically advanced platforms. CRISPR/Cas mRNA formulated in lipid nanoparticles is currently under clinical trials for treating hereditary transthyretin amyloidosis. Nonviral delivery of CRISPR/Cas systems in mRNA format not only minimizes immunogenicity and carcinogenicity, but also enables transient genome editing, thereby reducing potential off-target effects. The recent advances in the nonviral CRISPR/Cas mRNA delivery systems should facilitate CRISPR technologies toward clinical applications.
关键词	clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system mRNA nanomaterials nonviral delivery
相关链接	[来源记录]
收录类别	ESCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[82072053] ; Shenzhen Science and Technology Program[RCYX20200714114539061] ; Shenzhen Fundamental Research Foundation[JCYJ20190806150018265]
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
WOS类目	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号	WOS:000853917400001
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：10
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/402361
专题	南方科技大学第一附属医院南方科技大学医学院
作者单位	1.Jinan Univ, Dept Infect Dis, Shenzhen Peoples Hosp, Affiliated Hosp 1,Southern Univ Sci & Technol, Shenzhen 518020, Peoples R China 2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院; 南方科技大学医学院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Liu, Zhen,Li, Zhenghua,Li, Bin. Nonviral Delivery of CRISPR/Cas Systems in mRNA Format[J]. ADVANCED NANOBIOMED RESEARCH,2022.
APA	Liu, Zhen,Li, Zhenghua,&Li, Bin.(2022).Nonviral Delivery of CRISPR/Cas Systems in mRNA Format.ADVANCED NANOBIOMED RESEARCH.
MLA	Liu, Zhen,et al."Nonviral Delivery of CRISPR/Cas Systems in mRNA Format".ADVANCED NANOBIOMED RESEARCH (2022).