Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials

Ding，Lin1,2,3,4; Liang，Minli2,3,4; Li，Chenchen5; Ji，Xinting1; Zhang，Junfeng5; Xie，Weifen6; Reis，Rui L.7; Li，Fu Rong2,3,4; Gu，Shuo1; Wang，Yanli1

2022

10.1002/smtd.202200853

Small Methods   影响因子和分区

2366-9608

2366-9608

Conventional chemotherapy and radiotherapy are nonselective and nonspecific for cell killing, causing serious side effects and threatening the lives of patients. It is of great significance to develop more accurate tumor-targeting therapeutic strategies. Nanotechnology is in a leading position to provide new treatment options for cancer, and it has great potential for selective targeted therapy and controlled drug release. 2D nanomaterials (2D NMs) have broad application prospects in the field of tumor-targeted delivery systems due to their special structure-based functions and excellent optical, electrical, and thermal properties. This review emphasizes the design strategies of tumor-targeted delivery systems based on 2D NMs from three aspects: passive targeting, active targeting, and tumor-microenvironment targeting, in order to promote the rational application of 2D NMs in clinical practice.

2D nanomaterials delivery systems tumor-targeting strategies

SCI

英语

其他

Guangdong Basic and Applied Basic Research Foundation["2021A1515110657","2022A1515010056"] ; Shenzhen Science and Technology Program[RCBS20210609104513023] ; National Natural Science Foundation of China[81922037] ; Shanghai Biomedical Science and Technology Support Project[19441903600]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000859063000001

WILEY-V C H VERLAG GMBH

2-s2.0-85138619810

Scopus

1.School of Pharmaceutical Sciences and The First Affiliated Hospital,Hainan Medical University,Haikou,570228,China
2.The First Affiliated Hospital (Shenzhen People's Hospital),Southern University of Science and Technology,Shenzhen,518055,China
3.Translational Medicine Collaborative Innovation Center,Shenzhen People's Hospital (The First Affiliated Hospital,Southern University of Science and Technology,The Second Clinical Medical College of Jinan University),Shenzhen,Guangdong,518055,China
4.Guangdong Engineering Technology Research Centerof Stem Cell and Cell Therapy,Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation,Shenzhen Immune Cell Therapy Public Service Platform,Shenzhen,518020,China
5.Tumor Precision Targeting Research Center,School of Environmental and Chemical Engineering,Shanghai University,Shanghai,200444,China
6.Department of Gastroenterology,Changzheng Hospital,Naval Medical University,Shanghai,200003,China
7.3B's Research Group,I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics,University of Minho,Guimarães,4805-017,Portugal

Ding，Lin,Liang，Minli,Li，Chenchen,et al. Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials[J]. Small Methods,2022.

Ding，Lin.,Liang，Minli.,Li，Chenchen.,Ji，Xinting.,Zhang，Junfeng.,...&Wang，Yanli.(2022).Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials.Small Methods.

Ding，Lin,et al."Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials".Small Methods (2022).