南方科技大学知识苑(SUSTech KC): ANGPTL2 aggravates doxorubicin-induced cardiotoxicity via inhibiting DUSP1 pathway

题名	ANGPTL2 aggravates doxorubicin-induced cardiotoxicity via inhibiting DUSP1 pathway
作者	Liu, Cheng 1,2,3 ; Chen, Qiuling 2,4; Liu, Huadong 1,2,3
通讯作者	Liu, Huadong
发表日期	2022-09-01
DOI	10.1093/bbb/zbac156
发表期刊	BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 影响因子和分区
ISSN	0916-8451
EISSN	1347-6947
摘要	Angiopoietin-like protein 2 (ANGPTL2) plays versatile roles in various cardiovascular diseases. Its connection to doxorubicin (DOX)-related cardiomyopathy, however, remains elusive. To determine the role of ANGPTL2, an adeno-associated viral vector was used to overexpress ANGPTL2 in the murine heart 4 weeks before DOX treatment (15 mg/kg). Moreover, mice were injected with adenoviral vectors to knock down ANGPTL2 in the myocardium. Echocardiography and hemodynamics were used to determine the cardiac function. The effect of ANGPTL2 and its downstream target were elucidated by applying molecular and biochemical strategies. We found that ANGPTL2 expression was significantly increased in response to DOX stimulation. Moreover, cardiac-specific ANGPTL2 overexpression exacerbated DOX-related cardiac dysfunction, myocardial apoptosis, and oxidative stress. Mechanistically, ANGPTL2 aggravated DOX-induced cardiac injury via inhibiting the dual specificity phosphatase 1 (DUSP1) pathway and DUSP1 overexpression significantly impeded DOX-induced cardiomyopathy in ANGPTL2-overexpressed mice. Altogether, ANGPTL2 aggravated DOX-related cardiac injury by suppressing the DUSP1 pathway.
关键词	cardiomyopathy oxidative stress doxorubicin ANGPTL2 DUSP1
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Shenzhen Science and Technology Project[JCYJ20190806153207263] ; Shenzhen Key Medical Discipline Construction Fund["SZXK059","SZXK003"]
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
WOS类目	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology
WOS记录号	WOS:000864369900001
出版者	OXFORD UNIV PRESS
ESI学科分类	BIOLOGY & BIOCHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/405980
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Clin Med Coll 2, Dept Cardiol, Shenzhen Peoples Hosp, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 3.Shenzhen Cardiovasc Minimally Invas Med Engn Tech, Shenzhen, Peoples R China 4.Jinan Univ, Dept Pharm, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Liu, Cheng,Chen, Qiuling,Liu, Huadong. ANGPTL2 aggravates doxorubicin-induced cardiotoxicity via inhibiting DUSP1 pathway[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2022.
APA	Liu, Cheng,Chen, Qiuling,&Liu, Huadong.(2022).ANGPTL2 aggravates doxorubicin-induced cardiotoxicity via inhibiting DUSP1 pathway.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY.
MLA	Liu, Cheng,et al."ANGPTL2 aggravates doxorubicin-induced cardiotoxicity via inhibiting DUSP1 pathway".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2022).