南方科技大学知识苑(SUSTech KC): Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy

题名	Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy
作者	Lu, Song-Bo; Wei, Luyao; He, Wenjing; Bi, Zhen-Yu; Qian, Yuhan; Wang, Jinghan; Lei, Hongqiu; Li, Kai
通讯作者	Li, Kai
发表日期	2022-10-01
DOI	10.1002/open.202200137
发表期刊	ChemistryOpen 影响因子和分区
ISSN	2191-1363
卷号	11 期号:10
摘要	The exploration of advanced probes for cancer diagnosis and treatment is of high importance in fundamental research and clinical practice. In comparison with the traditional "always-on" probes, the emerging activatable probes enjoy advantages in promoted accuracy for tumor theranostics by specifically releasing or activating fluorophores at the targeting sites. The main designing principle for these probes is to incorporate responsive groups that can specifically react with the biomarkers (e. g., enzymes) involved in tumorigenesis and progression, realizing the controlled activation in tumors. In this review, we summarize the latest advances in the molecular design and biomedical application of enzyme-responsive organic fluorescent probes. Particularly, the fluorophores can be endowed with ability of generating reactive oxygen species (ROS) to afford the photosensitizers, highlighting the potential of these probes in simultaneous tumor imaging and therapy with rational design. We hope that this review could inspire more research interests in the development of tumor-targeting theranostic probes for advanced biological studies.
关键词	enzyme-activatable probes functional groups peptide-responsive photodynamic therapy tumor fluorescent imaging
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China["U21 A2097","31870991"] ; Department of Science and Technology of Guangdong Province["2022B1212010003","2019ZT08Y191","2019QN01Y640"] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Science and Technology Program["JSGG20200225151916021","KQTD20190929172743294"]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000864161900001
出版者	WILEY-V C H VERLAG GMBH
来源库	Web of Science
引用统计	被引频次[WOS]：7
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/405989
专题	工学院_生物医学工程系
作者单位	Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Peoples R China
第一作者单位	生物医学工程系
通讯作者单位	生物医学工程系
第一作者的第一单位	生物医学工程系
推荐引用方式 GB/T 7714	Lu, Song-Bo,Wei, Luyao,He, Wenjing,et al. Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy[J]. ChemistryOpen,2022,11(10).
APA	Lu, Song-Bo.,Wei, Luyao.,He, Wenjing.,Bi, Zhen-Yu.,Qian, Yuhan.,...&Li, Kai.(2022).Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy.ChemistryOpen,11(10).
MLA	Lu, Song-Bo,et al."Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy".ChemistryOpen 11.10(2022).