Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism

Wang, Mingzheng1,2; Cha, Ruitao2; Hao, Wenshuai1,2; Du, Ran3; Zhang, Pai1,2; Hu, Yingmo1; Jiang, Xingyu4

2022-09-01

10.1021/acsnano.2c05809

ACS Nano   影响因子和分区

1936-0851

1936-086X

Constipation can seriously affect the quality of life and increase the risk of colorectal cancer. The present strategies for constipation therapy have adverse effects, such as causing irreversible intestinal damage and affecting the absorption of nutrients. Nanocrystalline cellulose (NCC), which is from natural plants, has good biocompatibility and high safety. Herein, we used NCC to treat constipation assessed by the black stool, intestinal tissue sections, and serum biomarkers. We studied the effect of NCC on gut microbiota and discussed the correlation of gut microbiota and metabolites. We evaluated the long-term biosafety of NCC. NCC could effectively treat constipation through gut microbiota metabolism, which required a small dosage and did not affect the organs and intestines. NCC could be used as an alternative to medications and dietary fiber for constipation therapy.

nanocrystalline cellulose nanocellulose constipation gut microbiota metabolite

SCI

英语

NI论文

通讯

National Key R&D Program of China["2021YFF1200100","2018YFA0902600"] ; National Natural Science Foundation of China["21875050","32171397","81730051"] ; Natural Science Foundation of Shenzhen[JCYJ20190814163201896] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000862658200001

AMER CHEMICAL SOC

Web of Science

1.China Univ Geosci Beijing, Sch Mat Sci & Technol, Beijing Key Lab Mat Utilizat Nonmetall Minerals &, Natl Lab Mineral Mat, Beijing 100083, Peoples R Repub
2.Natl Ctr Nano Sci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R Repub
3.Chinese Acad Agr Sci, Guangdong Lab Lingnan Modern Agr, Shenzhen Key Lab Agr Synthet Biol, Genome Anal Lab,Minist Agr & Rural Affairs,Shenzhe, Shenzhen 518124, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Wang, Mingzheng,Cha, Ruitao,Hao, Wenshuai,et al. Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism[J]. ACS Nano,2022.

Wang, Mingzheng.,Cha, Ruitao.,Hao, Wenshuai.,Du, Ran.,Zhang, Pai.,...&Jiang, Xingyu.(2022).Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism.ACS Nano.

Wang, Mingzheng,et al."Nanocrystalline Cellulose Cures Constipation via Gut Microbiota Metabolism".ACS Nano (2022).