Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis

Zheng, Jiazhen1,2; Huang, Xihao3; Huang, Jinghan4; Meng, Bingyao5; Li, Furong6; Liu, Huamin5; Chen, Liren7; Zhou, Rui5; Zou, Mengchen8; Wu, Xianbo5

2022-10-01

10.1002/acr.24872

ARTHRITIS CARE & RESEARCH   影响因子和分区

2151-464X

2151-4658

Objective Emerging evidence indicates that hyperglycemia has an adverse impact on the knee joint which, in turn, may increase the risk of knee osteoarthritis (OA), but evidence from the real-life settings of large-scale cohort studies remains unclear. We sought to evaluate the association of glycemic control and the risk of symptomatic knee OA in a community-based cohort of older adults. Methods We conducted a prospective analysis of 10,730 participants without knee OA. Comprehensive blood biomarker data were obtained. Diabetes mellitus (DM) was defined mainly using a glycosylated hemoglobin (HbA(1c)) level of >= 6.5%; poor glycemic control in individuals with DM was defined as an HbA(1c) level of >= 7%. We fit Cox regression models, stratified according to DM status. We evaluated the hazards associated with HbA(1c) and fasting blood glucose levels using a spline model. Results During a median follow-up of 5 years, knee OA developed in 1,089 participants (108 with DM and 971 without). Knee OA was related to DM (hazard ratio [HR] 1.29 [95% confidence interval (95% CI) 1.02-1.78]), bad glycemic regulation in DM patients (HR 1.41 [95% CI 1.05-2.09]), and long-term DM (>= 5 versus <5 years; HR 1.49 [95% CI 1.02-2.17]). High levels of HbA(1c) (>7.7% and 61 mmoles/mole) and fasting blood glucose (>186 mg/dl) were significantly associated with higher risk of incident knee OA. Conclusion DM, bad glycemic management, and long-term DM are potential risk factors of symptomatic knee OA independent of age and body mass index. Targeting blood glucose, in addition to bodyweight, may be an important avenue for prevention of knee OA.

SCI

英语

其他

National Natural Science Foundation of China[82173607] ; Guangdong Basic and Applied Basic Research Foundation[2021-A1515011684] ; Open Project of the Guangdong Provincial Key Laboratory of Tropical Disease Research[2020-B1212060042] ; Guangzhou Science and Technology Project[202102080597]

Rheumatology

Rheumatology

WOS:000868948700001

WILEY

2-s2.0-85140013823

Web of Science

1.Hong Kong Univ Sci & Technol Guangzhou, Guangzhou, Peoples R China
2.Hong Kong Univ Sci & Technol, Clear Water Bay,Hong, Hong Kong, Peoples R China
3.Sichuan Univ, West China Hosp, Chengdu, Peoples R China
4.Boston Univ, Boston, MA 02215 USA
5.Southern Med Univ, Guangzhou, Peoples R China
6.Southern Univ Sci & Technol, Shenzhen, Peoples R China
7.Waseda Univ, Tokyo, Japan
8.Southern Med Univ, Nanfang Hosp, Guangzhou, Peoples R China

Zheng, Jiazhen,Huang, Xihao,Huang, Jinghan,et al. Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis[J]. ARTHRITIS CARE &amp; RESEARCH,2022,75(3):509-518.

Zheng, Jiazhen.,Huang, Xihao.,Huang, Jinghan.,Meng, Bingyao.,Li, Furong.,...&Wu, Xianbo.(2022).Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis.ARTHRITIS CARE & RESEARCH,75(3),509-518.

Zheng, Jiazhen,et al."Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis".ARTHRITIS CARE & RESEARCH 75.3(2022):509-518.