Five-membered carbocycle construction in the synthesis of Daphniphyllum alkaloids: recent strategic and methodological advances

Zhang, Xiaofeng1,2,3,4,5; Xu, Jing2,3,4,5,6

2022-10-01

10.1039/d2qo01410f

Organic Chemistry Frontiers   影响因子和分区

2052-4129

As the key structural unit, five-membered carbocycles are widely found in the framework of natural products. Among these molecules, Daphniphyllum alkaloids are particularly intriguing targets for synthetic chemists owing to their complex structures and interesting bioactivity. Within extensive synthetic studies of these alkaloids, various strategies and methods have been utilized for the construction of all carbon five-membered rings. Besides the classics, in this review we would like to focus on the novel or relatively rarely used strategies and methods for the five-membered carbocycle construction in recent Daphniphyllum alkaloid synthesis, covering from January 2017 to August 2022.

SCI ; EI

英语

通讯

National Natural Science Foundation of China["21971104","22271136"] ; Shenzhen Bay Laboratory[SZBL2019062801006] ; Guangdong Innovative Program[2019BT02Y335] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis[ZDSYS20190902093215877] ; Shenzhen Nobel Prize Scientists Laboratory Project[C17783101]

Chemistry

Chemistry, Organic

WOS:000867865200001

ROYAL SOC CHEMISTRY

20224513055990

Chemical Products Generally:804

Web of Science

1.Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Chemist, Shenzhen 518055, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
5.Southern Univ Sci & Technol, Shenzhen Key Lab Small Mol Drug Discovery & Synth, Shenzhen 518055, Peoples R China
6.Shenzhen Bay Lab, Shenzhen 518132, Guangdong, Peoples R China

Zhang, Xiaofeng,Xu, Jing. Five-membered carbocycle construction in the synthesis of Daphniphyllum alkaloids: recent strategic and methodological advances[J]. Organic Chemistry Frontiers,2022,9(23).

Zhang, Xiaofeng,&Xu, Jing.(2022).Five-membered carbocycle construction in the synthesis of Daphniphyllum alkaloids: recent strategic and methodological advances.Organic Chemistry Frontiers,9(23).

Zhang, Xiaofeng,et al."Five-membered carbocycle construction in the synthesis of Daphniphyllum alkaloids: recent strategic and methodological advances".Organic Chemistry Frontiers 9.23(2022).