南方科技大学知识苑(SUSTech KC): Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages

题名	Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages
作者	Geng, Aiai 1,2; Chen, Shanze 3; Ren, Laibin 3; Zhao, Xueyi 2; Pei, Tianli 1; Jia, Bo 1; Gong, Daoyin 4
通讯作者	Gong, Daoyin
发表日期	2022-08-18
DOI	10.1155/2022/3517020
发表期刊	Contrast Media & Molecular Imaging 影响因子和分区
ISSN	1555-4309
EISSN	1555-4317
卷号	2022
摘要	Pure plant extract luteolin has been demonstrated to possess numerous biological and immunological effects. However, how luteolin affects mice alveolar macrophages' self-renewal and polarization closely related to inflammatory and immunomodulatory is still unknown. In our study, the transcriptomic analysis showed that several self-renewal-related pathways in luteolin-pretreated alveolar macrophages were inhibited compared to the granulocyte-macrophage colony-stimulating factor (GM-CSF)-treated group. Ki-67 staining and EdU assay indicated that luteolin inhibited GM-CSF-induced alveolar macrophage proliferation. Moreover, GM-CSF-induced expressions of c-Myc and KLF4 were significantly suppressed by luteolin at transcriptional and protein levels. Besides, we found that luteolin promoted M1 macrophage polarization induced by LPS plus IFN-gamma. At the same time, it inhibited M2 macrophage polarization induced by IL-4 in both alveolar and bone marrow-derived macrophages by detecting macrophage polarization-related gene expressions at mRNA and protein levels. We found that luteolin inhibited self-renewal and altered the polarization of primary alveolar macrophages. Taken together, our data will aid in a better understanding of the immunomodulatory effects of luteolin on the primary alveolar macrophages.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	General project of National Natural Science Foundation of China[8187142249]
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000867389600002
出版者	WILEY-HINDAWI
来源库	Web of Science
引用统计	被引频次[WOS]：2
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/406535
专题	南方科技大学第一附属医院
作者单位	1.Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu 611137, Peoples R China 2.Shanxi Univ Tradit Chinese Med, Affiliated Hosp, Taiyuan 030024, Peoples R China 3.Southern Univ Sci & Technol, Inst Resp Dis, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China 4.Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610075, Peoples R China
推荐引用方式 GB/T 7714	Geng, Aiai,Chen, Shanze,Ren, Laibin,et al. Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages[J]. Contrast Media & Molecular Imaging,2022,2022.
APA	Geng, Aiai.,Chen, Shanze.,Ren, Laibin.,Zhao, Xueyi.,Pei, Tianli.,...&Gong, Daoyin.(2022).Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages.Contrast Media & Molecular Imaging,2022.
MLA	Geng, Aiai,et al."Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages".Contrast Media & Molecular Imaging 2022(2022).