南方科技大学知识苑(SUSTech KC): Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex

题名	Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
作者	Ravi，Anagh Sinha 1; Zeng，Menglong 2; Chen，Xudong 2; Sandoval，Gerardo 3,4; Diaz-Alonso，Javier 3,4; Zhang，Mingjie2,5,6 ; Nicoll，Roger A.1
通讯作者	Diaz-Alonso，Javier; Nicoll，Roger A.
发表日期	2022-10-11
DOI	10.1016/j.celrep.2022.111483
发表期刊	Cell Reports 影响因子和分区
ISSN	2211-1247
EISSN	2211-1247
卷号	41 期号:2
摘要	The critical role of AMPA receptor (AMPAR) trafficking in long-term potentiation (LTP) of excitatory synaptic transmission is now well established, but the underlying molecular mechanism is still uncertain. Recent research suggests that PSD-95 captures AMPARs via an interaction with the AMPAR auxiliary subunits—transmembrane AMPAR regulatory proteins (TARPs). To determine if such interaction is a core minimal component of the AMPAR trafficking and LTP mechanism, we engineered artificial binding partners, which individually were biochemically and functionally dead but which, when expressed together, rescue binding and both basal synaptic transmission and LTP. These findings establish the TARP/PSD-95 complex as an essential interaction underlying AMPAR trafficking and LTP.
关键词	AMPA receptor trafficking AMPAR CP: Neuroscience GluA1 LTP MAGUK postsynaptic density PSD-95 synaptic transmission TARP
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Shenzhen Graduate School, Peking University[S201101002];
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000879830500009
出版者	CELL PRESS
Scopus记录号	2-s2.0-85139736438
来源库	Scopus
引用统计	被引频次[WOS]：9
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/406575
专题	生命科学学院
作者单位	1.Department of Cellular and Molecular Pharmacology,University of California at San Francisco,San Francisco,United States 2.Division of Life Science,Hong Kong University of Science and Technology,Hong Kong,Clear Water Bay, Kowloon,Hong Kong 3.Department of Anatomy and Neurobiology,University of California at Irvine,Irvine,United States 4.Center for the Neurobiology of Learning and Memory,University of California at Irvine,Irvine,United States 5.Greater Bay Biomedical Innocenter,Shenzhen Bay Laboratory,Shenzhen,518036,China 6.School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China
推荐引用方式 GB/T 7714	Ravi，Anagh Sinha,Zeng，Menglong,Chen，Xudong,et al. Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex[J]. Cell Reports,2022,41(2).
APA	Ravi，Anagh Sinha.,Zeng，Menglong.,Chen，Xudong.,Sandoval，Gerardo.,Diaz-Alonso，Javier.,...&Nicoll，Roger A..(2022).Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex.Cell Reports,41(2).
MLA	Ravi，Anagh Sinha,et al."Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex".Cell Reports 41.2(2022).