Highly efficient conotoxin delivery enabled by a bio-derived ionic liquid

Liu, Tianqi1,2; Zhang, Jianhua3; Lu, Beibei1,2; Wang, Hao1,2; Zhan, Jingbo1,2; Tan, Xingchun3; Wu, Chengyu1,2; Liu, Shichao3; Wang, Zhenyuan1,2; Zhang, Jianglin4,5; Zhang, Jiaheng1,2

2022-12-01

10.1016/j.molliq.2022.120529

JOURNAL OF MOLECULAR LIQUIDS   影响因子和分区

0167-7322

1873-3166

Drug delivery remains a challenge in the field of medicine. Current administration methods limit the application of peptide-protein drugs. The non-injectable administration of polypeptide and protein drugs has frequently been a key research topic in the field of drug delivery. Conotoxins (CTX) are one class of these polypeptides, which shows excellent biological efficacy. However, CTX also has drawbacks because of its hydrophilicity and polarity, which restricts its application to invasive drug delivery such as injec-tions and significantly limits its clinical application. In this study, we developed an efficient and practical transdermal delivery system using an ionic liquid based on matrine and coconut oleic acid. In vitro pen-etration experiments demonstrated that the developed system could effectively deliver CTX to the dermis of the skin, with the cumulative absorption in the skin increased by 4.87 times. Moreover, the synergistic merits of ionic liquids and CTX contribute to the excellent antioxidant, antibacterial, and moisturizing effects at the cellular level. In addition, high safety was confirmed in animal experiments. In particular, the combined system exhibited outstanding efficacy for the improvement of skin elasticity and inhibiting wrinkle formation in population clinical tests. Therefore, this study expands the application of matrine-based ionic liquids in drug delivery and provides a novel methodology that promotes the efficiency of non-invasive drug delivery.(c) 2022 Elsevier B.V. All rights reserved.

Transdermal delivery Conotoxin Polypeptide Ionic liquids Non-invasive drug delivery

SCI

英语

通讯

[21905069] ; [U21A20307] ; [ZDSYS20190902093220279] ; [KQTD20170809110344233] ; [GXWD20201230155427003-20200821181245001] ; [GXWD202012 30155427003-20200821181809001] ; [ZX20200151] ; [2020A1515110879]

Chemistry ; Physics

Chemistry, Physical ; Physics, Atomic, Molecular & Chemical

WOS:000869467100002

ELSEVIER

CHEMISTRY

Web of Science

1.Harbin Inst Technol Shenzhen, Sch Mat Sci & Engn, State Key Lab Adv Welding & Joining, Shenzhen 518055, Peoples R China
2.Harbin Inst Technol, Res Ctr Printed Flexible Elect, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China
3.NOD topia Guangzhou Biotechnol Co Ltd, Guangzhou, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
5.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China

Liu, Tianqi,Zhang, Jianhua,Lu, Beibei,et al. Highly efficient conotoxin delivery enabled by a bio-derived ionic liquid[J]. JOURNAL OF MOLECULAR LIQUIDS,2022,367.

Liu, Tianqi.,Zhang, Jianhua.,Lu, Beibei.,Wang, Hao.,Zhan, Jingbo.,...&Zhang, Jiaheng.(2022).Highly efficient conotoxin delivery enabled by a bio-derived ionic liquid.JOURNAL OF MOLECULAR LIQUIDS,367.

Liu, Tianqi,et al."Highly efficient conotoxin delivery enabled by a bio-derived ionic liquid".JOURNAL OF MOLECULAR LIQUIDS 367(2022).